Felis ISSN 2398-2950

Fentanyl (parenteral)

Contributor(s): Sheilah Robertson, John Dodam, Claire Waters

Introduction

Name

  • Fentanyl.

Class of drug

  • Analgesic.
  • Opioid analgesic (narcotic).
  • Phenylpiperidene derivative.
  • Controlled substance - Class II opioid (US), Schedule II opioid (UK).

Description

Chemical name

  • N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide.

Molecular formula

  • C22H28N20

Molecular weight

  • 336.47

Physical properties

  • Clear, colorless solution for injection.
  • 1 ml solution contains 0.05 mg (50 micrograms) fentanyl (equivalent to 0.0785 mg fentanyl citrate).

Storage requirements

  • Shelf-life after opening 28 days.
  • Do not freeze.
  • Store together with product information.
  • If diluted (see Interactions) use immediately to ensure sterility. Dilutions may be stable chemically and physically for 4 hours at 25°C.
  • Must meet the storage requirements for Schedule II controlled drug   Controlled drugs: legal requirements for storage, prescription and supply  .

Uses

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Indications

  • Analgesia and sedation.
  • Given:
    EitherAlone.
    OrIn combination with other anesthetic agents, eg diazepam   Diazepam  or midazolam   Midazolam  . Often used as part of a balanced anesthetic maintenance protocol.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

Antitussives, pentobarbital, narcotic analgesics and tranquillizers
  • May cause additive central nervous system or respiratory depression when given with fentanyl.

Cimetidine

  • Cimetidine   Cimetidine  may cause increased plasma fentanyl concentrations.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references fromPubMed.

Other sources of information

  • Based onSmall Animal Formulary.Tennant B (1999) 3rd edn. Cheltenham: BSAVA.

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