ISSN 2398-2950      

Esmolol

ffelis

Introduction

Name

  • Esmolol.

Class of drug

  • Ultra short-acting beta blocker.

Description

Chemical name

  • (+/-)-Methyl-p-[2-hydroxy-3-(isopropylamino)propoxy]hydrocinnamate HCl.

Molecular formula

  • C16H26NO4.Cl.

Molecular weight

  • 331.8.

Physical properties

  • White crystalline powder.

Uses

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Indications

  • Treatment of supraventricular tachycardia

Administration

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Pharmacokinetics

Precautions

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Interactions

with other drugs

Sympathomimetics

Anesthetic agents, phenothiazines, antihypertensives, diazepam, diuretics and antiarrhythmics

  • Enhance hypotensive effect.

Calcium channel blockers

  • Diltiazem   Diltiazem  and verapamil   Verapamil  increase risk of bradycardia, severe hypotension, heart failure and AV block.

Digoxin

  • May increase [digoxin] by 20%.
  • Bradycardia increased by concurrent administration.

Thyroid hormones

  • Enhance metabolism of esmolol thus reduce effect.
  • Dose of esmolol should be decreased when initiating methimazole   Carbimazole  therapy.

Cimetidine

  • May decrease metabolism of esmolol.

Muscle relaxants

  • Esmolol enhances effects of suxamethonium   Suxamethonium  , tubocurarine.

Phenobarbitone and phenytoin

  • May increase rate of metabolism of esmolol by hepatic enzyme induction.

Theophylline

  • May block bronchodilatory effects of theophylline   Theophylline  .

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • BSAVA Small Animal Formulary. Ramsey I (2017) 9th edn. BSAVA, UK.
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