ISSN 2398-2950      

Erythromycin

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Introduction

Name

  • Erythromycin.

Class of drug

  • Macrolide antibiotic.

Description

Physical properties

  • Weak bases.
  • Available as salts or esters.

Uses

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Indications

  • Has similar, although not identical, antibacterial spectrum to penicillins.
  • Gram-positive infections.
    Some Staphylococci  Staphylococcus spp  are resistant - can be quite high.
  • Gram-positive bacilli and some Gram-negative infections, eg Pasturella spp.
  • Some strains of ActinomycesNocardia  Nocardia spp  , Chlamydia and Rickettsia.
    Most strains of the enterobacteriaceae, eg Pseudomonas spp   Pseudomonas spp  , Escherichia coli  Escherichia coli  , Klebsiella spp, are resistant.
  • Penetrates soft tissues including skin; useful in treatment of prostatitis .

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Methylprednisolone
  • Erythromycin may increase serum levels   Methylprednisolone  .
    Theophylline
  • Erythromycin may increase serum levels   Theophylline  .
    Terfenadine
  • Erythromycin may increase serum levels. In humans the interaction with terfenadine   Terfenadine  has led to fatal arrhythmias.
    Warfarin.
  • Erythromycin may increase serum levels   Warfarin  .
    Digoxin
  • Erythromycin may enhance the absorption of digoxin   Digoxin  from the GI tract.

Adverse Reactions

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Further Reading

Publications

Refereed Papers

Other sources of information

  • Based on Small Animal Formulary. Tennant B (1999) 3rd edn. BSAVA, UK.
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