Felis ISSN 2398-2950

Erythromycin

Contributor(s): Lauren Trepanier

Introduction

Name

  • Erythromycin.

Class of drug

  • Macrolide antibiotic.

Description

Physical properties

  • Weak bases.
  • Available as salts or esters.

Uses

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Indications

  • Has similar, although not identical, antibacterial spectrum to penicillins.
  • Gram-positive infections.
    SomeStaphylococci  Staphylococcus spp  are resistant - can be quite high.
  • Gram-positive bacilli and some Gram-negative infections, egPasturellaspp.
  • Some strains ofActinomyces,Nocardia  Nocardia spp  ,ChlamydiaandRickettsia.
    Most strains of the enterobacteriaceae, egPseudomonasspp   Pseudomonas spp  ,Escherichia coli  Escherichia coli  ,Klebsiellaspp, are resistant.
  • Penetrates soft tissues including skin; useful in treatment of prostatitis .

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

Methylprednisolone
  • Erythromycin may increase serum levels   Methylprednisolone  .
    Theophylline
  • Erythromycin may increase serum levels   Theophylline  .
    Terfenadine
  • Erythromycin may increase serum levels. In humans the interaction with terfenadine   Terfenadine  has led to fatal arrhythmias.
    Warfarin.
  • Erythromycin may increase serum levels   Warfarin  .
    Digoxin
  • Erythromycin may enhance the absorption of digoxin   Digoxin  from the GI tract.

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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