Felis ISSN 2398-2950

Eprinomectin

Contributor(s): Vetstream Ltd, Linda Horspool

Introduction

Name

  • Eprinomectin.

Class of drug

  • Avermectin.
  • Macrocyclic lactone.

Description

Chemical name

  • (1'R,2S,4'S,5S,6R,8'R,10'E,12'S,13'S,14'E,16'E,20'R,21'R,24'S)-21',24'-Dihydroxy-6-isopropyl-5,11',13',22'-tetramethyl-2'-oxo-5,6-dihydrospiro[pyran-2,6'-[3,7,19]trioxatetracyclo[15.6.1.14,8.020,24 ]pentacosa[10,14,16,22]tetraen]-12'-yl 4-O-(4-acetamido-2,4,6-trideoxy-3-O-methyl-α-L-lyxo-hexopyranosyl)-2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranoside - (1'R,2S,4'S,5S,6R,8'R,10'E,12'S,1 3'S,14'E,16'E,20'R,21'R,24'S)-6-[(2S)-2-buta.                  

Molecular formula

  • C99H148N2O28.

Molecular weight

  • 1814.231.

Physical properties

  • Spot-on solution in combination with praziquantel (Centragard, US).
  • Spot-on solution in combination with fipronil, (S)-methoprene, praziquantel (Broadline, EU).

Uses

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Indications

  • For cats with, or at risk from, mixed infestations with nematodes and cestodes and ectoparasites.
  • Eprinomectin spectrum of efficacy includes gastrointestinal and extra-intestinal nematodes.
 
Centragard (US)
Broadline (Europe)
Roundworm
Treatment and control of adult and
L4 larvae Toxocara cati
Treatment of adult and L4 and L3 larvae
of Toxocara cati and adult Toxascaris leonina
Hookworm
Treatment and control of adult L4 larvae of
Ancylostoma tubaeforme and adult
Ancylostoma braziliense
Treatment of adult and L4 larvae of Ancylostoma
tubaeforme
and adult Ancylostoma braziliense
Heartworm
Prevention of heartworm disease (Dirofilaria immitis larvae) for one month
Lungworm
-
Treatment adult and L4 and L3 Aelurostrongylus
abstrusus
and adult and L4 Troglostrongylus brevior
Bladder
-
Treatment of Capillaria plica

Administration

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Pharmocokinetics

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Precautions

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Interactions

  • May interact with other p-glycoprotein substrates such as ciclosporin Ciclosporin, itraconazole Itraconazole, loperamide Loperamide and many steroids or opiates (but none reported).

Adverse Reactions

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Further Reading

Publications

Refereed Papers

  • Recent references from VetMedResource and PubMed.
  • Giannelli A, Brianti E, Varcasia A et al (2015) Efficacy of Broadline® spot-on against Aelurostrongylus abstrusus and Troglostrongylus brevior lungworm in naturally infected cats from Italy. Vet Parasito209 (3-4), 273-277 PubMed.
  • Knaus M, Shukullari E, Rapti D et al (2015) Efficacy of Broadline against Capillaria aerophila lungworm infection in cats. Parasitol Res 114 (5), 1971-1975 PubMed
  • Baker C F, Tielemans E, Pollmeier M G et al (2014) Efficacy of a single dose of a novel topical combination product containing eprinomectin to prevent heartworm infection in cats. Vet Parasitol 202 (1-2), 49-53 PubMed
  • Knaus M, Abu-Madi M A, Ibarra-Velarde F et al (2014) Efficacy of a novel topical fipronil, (S)-methoprene, eprinomectin and praziquantel combination against naturally acquired intestinal nematode and cestode infection in cats. Vet Parasitol 202 (1-2), 18-25 PubMed
  • Knaus M, Baker C F, Reinemeyer C R et al (2014) Efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel against adult and larval stages of Toxocara cati in cats. Vet Parasitol 202 (1-2), 34-39 PubMed.
  • Knaus M, Chester S T, Rosentel J et al (2014) Efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel against larval and adult stages of the cat lungworm, Aelurostrongylus abstrususVet Parasitol 202 (1-2), 64-68 PubMed.
  • Knaus M, Shukallari E, Rosental J et al (2014) Efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel against feline urinary bladder worm (Capillaria plica) infection. Vet Parasitol 202 (1-2), 45-48 PubMed.
  • Knaus M, Theodore Chester S, Rosentel J et al (2014) Efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel against experimental infections of Toxascaris leonina in cats. Vet Parasitol 202 (1-2), 40-44 PubMed.
  • Kvaternick V, Kellermann M, Knaus M et al (2014) Pharmacokinetics and metabolism of eprinomectin in cats when administered in a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel. Vet Parasito202 (1-2), 2-9 PubMed
  • Prullage J B, Knaus M, Bowman D D et al (2014) Efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel against induced infections of Ancylostoma spp. nematodes of cats. Vet Parasitol 202 (1-2), 30-33 PubMed.
  • Rehbein S, Capári B, Duscher G et al (2014) Efficacy against nematode and cestode infections and safety of a novel topical fipronil, (S)-methoprene, eprinomectin and praziquantel combination product in domestic cats under field conditions in Europe. Vet Parasitol 202 (1-2), 10-17 PubMed.

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