ISSN 2398-2950      

Epirubicin

ffelis

Synonym(s): Pharmacorubicin


Introduction

Name

  • Epirubicin (4'-Epi-doxorubicin).

Class of drug

  • Cytotoxic anthracycline glycoside antibiotic.

Description

Chemical name

  • (8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione.

Molecular formula

  • C27H29NO11.

Storage requirements

  • After reconstitution the drug is stable for 24 h at room temperature.
  • Protect from light.

Uses

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Indications

  • In the dog, the drug has only been assessed against lymphomas.
  • It has not been evaluated in cats.
  • In man, epirubicin has demonstrated efficacy against human breast, ovarian, pancreatic, lung, gastric, bladder, thyroid, hepatic, colorectal and cervical neoplasms.
  • It may be used alone or with other anti-neoplastic therapies.

Administration

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Precautions

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Interactions

with diagnostic tests

  • Dogs should be periodically monitored with ECGs and/or echocardiograms.
  • Complete CBC and platelet count should be monitored whenever therapy is given. If the neutrphil count drops below 3x10³/dl (2x10*9/l) or if the platelet count drops below 150x10³/dl (50x10*9/l), treatment should be suspended. Once the counts have stabilized doxorubicin can then be restarted at the same dose.
  • If hematological toxicity occurs again, or if gastrointestinal toxicity is recurrent the dose should be reduced to 25 mg/m².

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Fischer D S, Knobf M T et al (2003) The Cancer Chemotherapy Handbook. 6th edn. Mosby, USA. pp 113-114.
  • Based on Small Animal Formulary. Tennant B (1999) 3rd edn. BSAVA, UK.
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