Felis ISSN 2398-2950

Epinephrine

Synonym(s): Adrenalin, adrenaline

Contributor(s): Vetstream Ltd, Jo Murrell

Introduction

Name

  • Epinephrine.

Class of drug

  • Catecholamine with both alpha and beta adrenergic activity.

Description

Chemical name

  • 4-[1-hydroxy-2-(methylamino)ethyl]1,2 benzenediol.

Physical properties

  • Microcrystalline white powder.

Storage requirements

  • Epinephrine is sensitive to light and air, and is unstable in 5% dextrose.
  • In a tight container.
  • Protected from light.

Uses

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Indications

Administration

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Pharmacokinetics

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Precautions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Interactions

with other drugs

  • Toxicity may occur if used with other sympathomimetic amines (eg isoproterenol Isoproterenol) because of additive effects.
  • The effects of epinephrine may be potentiated by antihistamines (eg chlorpheniramine Chlorphenamine, diphenhydramine Diphenhydramine) and thyroxine.
  • Propranolol Propranolol may block the beta effects of epinephrine, thus facilitating an increase in blood pressure.
  • Alpha blocking agents or diuretics may negate or diminish the pressor effects of epinephrine.
  • When epinephrine is used with drugs that sensitize the myocardium (eg halothane Halothane, high doses of digoxin Digoxin) monitor for signs of arrhythmias.
  • Try to avoid the use of epinephrine in halothane-anesthetized animals Halothane.
  • Hypertension may result if epinephrine is used with oxytocic agents Oxytocin.

Adverse Reactions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Further Reading

Publications

Refereed papers

Other sources of information

  • Rosanski E A, Rush J E, Buckley G J, Fletcher D J, Boller M; RECOVER Advanced Life Support Domain Worksheet Authors (2012) RECOVER evidence and knowledge gap analysis on veterinary CPR. Part 4: Advanced life support. J Vet Emerg Crit Care (San Antonio) 22 (Suppl 1), S44-64 PubMed.
  • Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

ADDED