Felis ISSN 2398-2950

Ephedrine

Synonym(s): Ephedrine sulphate, Ephedrine hydrochloride, Enurace

Contributor(s): Vetstream Ltd, Gigi Davidson

Introduction

Name

  • Ephedrine.

Class of drug

  • Sympathomimetic alkaloid.
  • Mixed alpha- and beta-adrenergic agonist, by causing the release of norepinephrine.

Description

Chemical name

  • (R*,S*)-2-(methylamino)-1-phenylpropan-1-ol.

Molecular formula

  • C10H15NO.

Molecular weight

  • 165.23 g.

Physical properties

  • Fine, odorless, white crystals or powder.
  • Approximately 770 mg are soluble in 1 mL of water.
  • Colorless aqueous solution.

Storage requirements

  • Room temperature.
  • Protect from light.
Considered a controlled substance in the US due to use in methamphetamine manufacturing.

Uses

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Indications

Administration

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Pharmocokinetics

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Precautions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Interactions

With other drugs

  • Should not be used with other sympathomimetic agents or monoamine oxidase inhibitors, eg selegeline.
  • Volatile anesthetics will enhance the sensitivity of the myocardium to the effects of ephedrine.
  • Concomitant use with cardiac glycosides (digoxin Digoxin) and tricyclic antidepressants (amitriptyline) can cause arhythmias.

Adverse Reactions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Further Reading

Publications

Refereed Papers

Other sources of information

  • Ramsey I (2017) BSAVA Small Animal Formulary. 9th edn. British Small Animal Association. pp 141.
  • Plumb D (2015) Plumb's Veterinary Drug Handbook. 8th edn. Wiley-Blackwell. pp 1296.
  • Ko J (2009) Anesthesia Monitoring Techniques and Management. Proceedings of the Atlantic Coast Veterinary Conference.
  • Peck T E, Hill S A & Williams M (2005) Sympathomimetics. In: Pharmacology for Anaesthesia and Intensive Care. Greenwich Medical Media, London, UK. pp 187-208.

ADDED