Felis ISSN 2398-2950

Doxorubicin

Contributor(s): William Brewer Jr, Laura Garrett

Introduction

Name

  • Doxorubicin.

Class of drug

Uses

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Indications

  • Lymphosarcoma   Lymphoma  .
  • Hemangiosarcoma.
  • Lymphoma, soft tissue sarcomas (including vaccine associated sarcomas) and mammary carcinomas in the cat.
  • It may be used alone or in combination with other antineoplastic therapies.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

Digoxin
  • Reduction in serum digoxin   Digoxin  levels.

Barbiturate

  • Increases plasma clearance of doxorubicin.

Cyclophosphamide  Cyclophosphamide 

  • Increases risk of cardiotoxicity and cyclophosphamide-induced cystitis.

Heparin

  • Forms precipitate with Doxorubicin.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Kristal O, Lana S Eet al(2001)Single agent chemotherapy with doxorubicin for feline lymphoma: a retrospective study of 19 cases (1994-1997).JVIM15, 125-130.
  • Peaston A E & Maddison J E (1999)Efficacy of doxorubicin as an induction agent for cats with lymphosarcoma.Aust Vet J77(7), 442-444.
  • Zwahlen C H, Lucroy M D et al(1998)Results of chemotherapy for cats with alimentary malignant lymphoma: 21 cases (1993-1997).JAVMA213(8), 1144-1149.
  • Hahn K A, Frazier D Ket al(1997)Effect of infusion regime on doxorubicin pharmacokinetics in the cat.JAAHA33(5), 427-433.
  • O'Keefe D A, Sisson D Det al(1993)Systemic toxicity associated with doxorubicin administration in cats.J Vet Intern Med7(5), 309-317.

Other sources of information

  • Fischer D S, Knobf M Tet al(2003)The Cancer Chemotherapy Handbook.6th edn. Philadelphia, PA, Mosby. pp 109-111.
  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA. ISBN: 0 9052 1452 8.
  • Plumb D (1999)Veterinary Drug Handbook.3rd Edn. Iowa State University Press.
  • Fraizier D L & Hahn K A (1995)Commonly Used Drugs.In: Hahn K A & Richardson R C (eds)Cancer Chemotherapy A Veterinary Handbook. Philadelphia, PA. Williams & Wilkins. pp 102-103.

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