Felis ISSN 2398-2950

Doxepin

Synonym(s): Sinequan

Contributor(s): Rosanna Marsella

Introduction

Name

  • Doxepin.

Class of drug

  • Tricyclic antidepressant.

Description

Chemical name

  • 3-Dibenz[b,e]oxepin-11(6H)-ylidene-N,N-dimethyl-1-propanamine.

Molecular formula

  • C19H21NO.

Physical properties

  • Soluble in alcohol.

Storage requirements

  • Light resistant container.

Uses

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Indications

  • Management of pruritus and psychogenic dermatoses   Psychogenic alopecia  where there is a component of anxiety.
    Doxepin is less cardiotoxic than other tricyclics.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • Cimetidine   →   decreased metabolism   →   increased concentration doxepin.
    Anesthetics and anti-arrhythmics
  • Increased risk of arrhythmias.
    Anti-epileptics
  • Tricyclics antagonize the effects of anti-epileptics.
    Sedatives
  • Enhanced sedative effect.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Gido C, Langguth P & Mutschler E (1994)Predictions of in vivo plasma concentrations from in vitro release kinetics - application to doxepin parenteral (i.m.) suspension in lipophilic vehicles in dogs.Pharm Res11(6), 800-808.
  • Brown T C & Leversha A (1979)Comparison of the cardiovascular toxicity of three tricyclic antidepressant drugs - imipramine, amitryptyline, and doxepin.Clin Toxicol14(3), 253-256.

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.
  • Plumb DVeterinary Drug handbook.3rd edn. pp 261-262.

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