Felis ISSN 2398-2950

Doxapram

Synonym(s): Dopram-V

Contributor(s): Elizabeth Rozanski

Introduction

Name

  • Doxapram.

Class of drug

  • Central nervous system (CNS)/respiratory stimulant.

Uses

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Indications

  • Doxapram may be used to stimulate respiration in certain types of peri-operative respiratory depression, and in neonates.
  • Doxapram is preferred to naloxone when respiration is depressed by high doses of opioids, in animals which have undergone major surgery, as it does not affect opioid induced analgesia. However in these circumstances doxapram activity is short lived and may be followed by profound respiratory depression unless repeated doses or an infusion is given. Alternatively, an opioid antagonist may be given.
  • Doxapram may be given to differentiate central (anesthetic overdose) from peripheral (neuromuscular blockade) causes of respiratory depression in animals given non-depolarizing muscle relaxants.

Administration

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Pharmocokinetics

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Precautions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Interactions

with other drugs

  • Hypertension may occur with sympathomimetics.
  • The use of theophylline   Theophylline  concurrently with doxapram may cause increased CNS stimulation.
  • As doxapram may stimulate the release of epinephrine   Epinephrine  , its use within 10 minutes of the administration of anesthetic agents that sensitize the myocardium to catecholamines, eg halothane   Halothane  or enflurane, should be avoided.
  • Doxapram may mask the effects of muscle-relaxant drugs.
  • Doxapram is compatible with 5% dextrose or normal saline, but is incompatible with aminophylline   Aminophylline  , sodium bicarbonate   Sodium bicarbonate  and thiopental   Thiopental  .

Adverse Reactions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

ADDED