ISSN 2398-2950      

Diltiazem

ffelis
Contributor(s):

Mark Rishniw


Introduction

Name

  • Diltiazem.

Class of drug

  • Class IV antidysrhythmic agent.
  • Calcium channel blocker.

Description

Chemical name

  • 1,5-benzothiazepim-4(5H)one,3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-monohydrochloride,(+)-cis-.

Molecular weight

  • 451.

Uses

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Indications

Primary uses
  • To control supraventricular tachycardias.
  • Sustained and paroxysmal ventricular tachycardias   Ventricular premature contraction  particularly in cases of hypertrophic cardiomyopathy.
  • To slow heart rate in dogs with atrial fibrillation as an adjunct to digoxin   Digoxin  .
  • Management of hypertrophic cardiomyopathy.

Other conditions

  • Management of hypertension   Hypertension  .
  • To limit CNS damage following trauma.

Miscellaneous

  • Preferred to verapamil by many because it has effective anti-arrhythmic properties with minimal negative inotropy.
  • Diltiazem is preferred to B-blockers for the management of feline hypertrophic cardiomyopathy by some authors because it improves myocardial relaxation, increases ventricular filling and dilates coronary vasculature.

Administration

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Pharmacokinetics

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Precautions

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Interactions

with other drugs

Beta-adrenergic blockers, eg propranolol
  • If administered concurrently with propranolol   Propranolol  there may be additive negative inotropic and chronotropic effects.

Calcium salts, Vitamin D

Cimetidine

  • Cimetidine   Cimetidine  inhibits the metabolism of diltiazem thereby increasing plasma concentrations.

Theophylline

  • Theophylline   Theophylline  diltiazem enhances the effect, which may lead to toxicity.

Protein bound agents, eg warfarin

  • Diltiazem may displace warfarin   Warfarin  .

Publications

Refereed papers

Other sources of information

  • Based on Small Animal Formulary. Tennant B (1999) 3rd edn. BSAVA, UK.
MEMBER BENEFIT

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!