Felis ISSN 2398-2950

Diazepam

Contributor(s): Kyle Braund

Introduction

Name

  • Diazepam.

Class of drug

  • Benzodiazepine.
  • Schedule IV Controlled Substance.

Uses

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Indications

  • Premedicant.
  • Anticonvulsant.
  • Anxiolytic.
  • Muscle relaxant, eg Scotty cramp , urethral muscle spasm, tetanus   Tetanus  .
  • Appetite stimulant.
  • Spraying.
  • Anesthesia (small mammal/bird).
  • May be used with ketamine to offset the muscle hypertonicity associated with dissociative anesthesia.
  • Used in combination with acepromazine   Acepromazine maleate  and/or opioids for preanesthetic medication in the critically ill patient.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

Cimetidine, erythromycin, and omeprazole

Beta1 antagonists

  • Duration of action of diazepam may be prolonged.
  • Hypotension may be enhanced if diazepam is used in conjunction with propranolol.

Antihistamines or opioid analgesics

  • Sedative effect may be enhanced.

Digoxin

  • The effects of digoxin   Digoxin  may be increased.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Podell M (1998)Antiepileptic drug therapy.Clin Tech Small Anim Pract.13(3), 185-192.
  • Quesnel A D, Parent J M & McDonell W (1997)Clinical management and outcome of cats with seizure disorders: 30 cases (1991-1993).J Am Vet Med Assoc.210(1), 72-77

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.
  • Plumb DC (1999)Veterinary Drug Handbook. 3rd edn. Iowa State University Press, Ames. pp 184-187.

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