Felis ISSN 2398-2950

Deslorelin

Synonym(s): Suprelorin®

Contributor(s): Monica Ptaszynska, Angelika von Heimendahl

Introduction

Name

  • Deslorelin.

Class of drug

  • Gonadotrophin-releasing hormone (GnRH) agonist.

Description

Chemical name

  • Available veterinary formulation contains deslorelin as deslorelin acetate.

Physical properties

  • White to pale yellow cylindrical implant (size of a microchip).
  • Implant is supplied in a pre-loaded implanter.

Storage requirements

  • Store in refrigerator (2-8°C).
  • Do not freeze.
  • Shelf-life of product packaged for sale: 2 years.

Uses

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Indications

  • For the induction of temporary infertility in healthy, entire, sexually mature male dogs and ferrets.
    Deslorelin available as veterinary formulation is not licensed for use in cats.

Reported indications off-label uses in cats

Male cats

  • Induction of temporary infertility and reduction of libido.

Female cats

  • Treatment with slow release formulations of deslorelin was reported as temporary inhibition of estrous cycle and ovulation.
  • Due to the initial stimulation of FSH and LH release, deslorelin in slow release formulation was used for induction of estrus and ovulation in female cats.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • None known.

Warnings for personnel handling the product

  • Women in childbearing age should avoid contact with the product or wear disposable plastic gloves when handling the product.
  • Pregnant women should handle the product with extreme care.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed.
  • Novotny R A, Cizek P, Vitasek R, Bartoskova, Prinosilova P, Janosovska M (2012)Reversible suppression of sexual activity in tomcats with deslorelin implant.Theriogenology78, 848-857PubMed.
  • Toydemir T S, Kilicarslan M R, Olgac V (2012)Effects of GnRH analogue deslorelin implants on reproduction in female domestic cats.Theriogenology77, 662-674PubMed.
  • Fontaine E, Fontbonne A (2011)Clinical use of GnRH agonists in canine and feline species.Reprod Domest Anim46, 344-353 PubMed.
  • Goericke-Pesch S, Georgiev P, Antonov A, Albouy M, Wehrend A (2011)Clinical efficacy of a GnRH-agonist implant containing 4.7 mg deslorelin, Suprelorin, regarding suppression of reproductive function in tomcats.Theriogenology75, 803-810PubMed.
  • Trigg T, Doyle A, Walsh J, Swangchan-uthai T (2006)A review of advances in the use of the GnRH agonist deslorelin in control of reproduction.Theriogenology66,1507-1512 PubMed.
  • Munson L, Bauman J E, Asa C S, Jochle W, Trigg T E (2001)Efficacy of the GnRH analogue deslorelin for suppression of oestrous cycles in cats.J Reprod Fertil57, 269-273PubMed.

Organisation(s)

  • Peptech Animal Health, Australia;  www.peptech.com 
  • Virbac Ltd, Woolpit Business Park, Bury St Edmonds, Suffolk IP30 9UP, UK.

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