Felis ISSN 2398-2950

Desflurane

Introduction

Name

  • USAN.

Class of drug

  • Inhalation anesthetic.

Description

Molecular formula

  • Difluoromethyl 1-fluoro-2,2,2-trifluoroethyl ether.

Physical properties

  • Blood/gas partition coefficient: 0.42 (Halothane: 2.3, Isoflurane: 1.4).
  • Oil/gas partition coefficient: 18.7 (Halothane: 224, Isoflurane: 98).
  • MAC: 6-8% (Halothane: 0.8, Isoflurane: 1.2).
  • Highly volatile (saturated vapor pressure 700 mmHg).

Storage requirements

  • Store in an airtight container.
  • Protect from light.

Uses

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Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • Enhances effect ofcompetitivemuscle relaxants.

Further Reading

Publications

Other sources of information

  • Clinical Anaesthetic Pharmacology, Editors: John W Dundee, R.S.J.Clarke, William McCaughey. Pub: Churchill Livingstone. 1991.
  • Martindale - The Extra PharmacopoeiaThe London Pharmaceutical Society. 31st Edition.
  • Lumb and Jones. Veterinary AnaesthesiaWilliams and Williams 3rd Edition 1996.
  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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