Felis ISSN 2398-2950

Cyclophosphamide

Contributor(s): William Brewer Jr, Laura Garrett

Introduction

Name

  • Cyclophosphamide.

Class of drug

  • Nitrogen mustard group.

Description

Chemical name

  • N,N-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide monohydrate.
  • 2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazophosphorine 2-oxide monohydrate.

Molecular formula

  • C7H15Cl2N2O2P.H2O.

Physical properties

  • Lyophilized powder.
  • Tablets.
  • Tablets.

Storage requirements

  • Room temperature.
  • Reconstituted powder stable for 24 hours at room temperature and for 6 days under refrigeration.

Uses

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Indications

Administration

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Pharmocokinetics

Precautions

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Interactions

with other drugs

Digoxin

  • See also digoxin   Digoxin  .
  • Absorption of orally-administered digoxin may be decreased. This may occur several days after the cyclophosphamide is administered.

Barbiturates

  • Increase cyclophosphamide toxicity (increased rate of conversion to metabolites)   Phenobarbital  .

Phenothiazines

  • Reduce cyclophosphamide efficacy (by inhibiting activation of P450 enzymes which activate cyclophosphamide).

Chloramphenicol and corticosteroids

  • Reduce cyclophosphamide efficacy (by inhibiting activation of P450 enzymes which activate cyclophosphamide)   Chloramphenicol  .

Doxorubicin

with diagnostic tests

  • Frequent urinalysis is recommended for the early detection of hemorrhagic cystitis.

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Fischer D S, Knobf M Tet al(2003)The Cancer Chemotherapy Handbook. 6th edn. Philadelphia, PA, Mosby. pp 90-92.
  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.
  • Plumb D (1999)Veterinary Drug Handbook.3rd Edn. Iowa State University Press.
  • Fraizier D L & Hahn K A (1995)Commonly Used Drugs.In: Hahn K A & Richardson R C (eds)Cancer Chemotherapy A Veterinary Handbook.Philadelphia, PA. Williams & Wilkins. pp 94-95.

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