ISSN 2398-2950      

Cyclophosphamide

ffelis

Introduction

Name

  • Cyclophosphamide.

Class of drug

  • Nitrogen mustard group.

Description

Chemical name

  • N,N-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide monohydrate.
  • 2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazophosphorine 2-oxide monohydrate.

Molecular formula

  • C7H15Cl2N2O2P.H2O.

Physical properties

  • Lyophilized powder.
  • Tablets.
  • Tablets.

Storage requirements

  • Room temperature.
  • Reconstituted powder stable for 24 hours at room temperature and for 6 days under refrigeration.

Uses

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Indications

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Digoxin

  • See also digoxin   Digoxin  .
  • Absorption of orally-administered digoxin may be decreased. This may occur several days after the cyclophosphamide is administered.

Barbiturates

  • Increase cyclophosphamide toxicity (increased rate of conversion to metabolites)   Phenobarbital  .

Phenothiazines

  • Reduce cyclophosphamide efficacy (by inhibiting activation of P450 enzymes which activate cyclophosphamide).

Chloramphenicol and corticosteroids

  • Reduce cyclophosphamide efficacy (by inhibiting activation of P450 enzymes which activate cyclophosphamide)   Chloramphenicol  .

Doxorubicin

with diagnostic tests

  • Frequent urinalysis is recommended for the early detection of hemorrhagic cystitis.

Adverse Reactions

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Further Reading

Publications

Refereed Papers

Other sources of information

  • Fischer D S, Knobf M T et al (2003) The Cancer Chemotherapy Handbook. 6th edn. Mosby, USA. pp 90-92.
  • Based on Small Animal Formulary. Tennant B (1999) 3rd edn. BSAVA, UK.
  • Plumb D (1999) Veterinary Drug Handbook. 3rd Edn. Iowa State University Press.
  • Fraizier D L & Hahn K A (1995)Commonly Used Drugs. In: Cancer Chemotherapy A Veterinary Handbook. Eds: Hahn K A & Richardson R C. Williams & Wilkins, USA. pp 94-95.
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