Felis ISSN 2398-2950

Clodronate

Synonym(s): Bonefos, Loron

Introduction

Name

  • Clodronate.

Class of drug

  • Biphosphonate.

Description

Chemical name

  • (Dichloromethylene)bisphosphonic acid;(dichloromethylene)diphosphonic acid; dichloromethanediphosphonic acid; CL2MDP; DMDP.

Molecular formula

  • CH4Cl2O6P2.

Uses

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Indications

  • Use to treat acute moderate to severe hypercalcemia when other therapies are ineffective.
  • Use for long term therapy of chronic hypercalcemia.
    There are very few reports of the use of this drug in dogs.

Administration

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Precautions

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Interactions

with other drugs

Antacids, calcium and iron salts
  • Reduced absorption is seen if administered with antacids, calcium and iron salts.
    Administer 2 hours apart.

Aminogylosides

  • Concurrent use may result in severe hypocalcemia.

Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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