Felis ISSN 2398-2950

Clindamycin

Synonym(s): Antirobe

Contributor(s): Stephen Barr, Lauren Trepanier

Introduction

Name

  • Clindamycin.

Class of drug

  • Lincosamide antibiotic.
  • Bacteriostatic or bactericidal, depending on concentration.

Description

Chemical name

  • (2S-trans)-methyl 7-chloro-6,7,8-trideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-L-threo-alpha-D-galacto-octopyranoside.

Molecular formula

  • C18H22ClN2O5S.

Physical properties

  • Multi-colored capsules.

Storage requirements

  • <25°C.
  • Do not refrigerate.

Uses

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Indications

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

Cross-resistance
  • Complete cross-resistance between lincomycin   Lincomycin  and clindamycin.
  • Partial cross-resistance with erythromycin   Erythromycin  .

Non-depolarizing muscle relaxants (eg tubocurarine)

  • May be increased by clindamycin.

Neostigmine and pyridostigmine

Erythromycin

  • See also erythromycin   Erythromycin  .
  • Antagonize each other's effectsin vitro; clinical significance unknown.

Clindamycin can cause neuromuscular blockade; avoid use with aminoglycosides or anesthetic neuromuscular blockade.

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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