Felis ISSN 2398-2950

Cisapride

Synonym(s): Prepulsid

Introduction

Name

  • Cisapride.

Class of drug

  • Prokinetic agent.

Description

Chemical name

  • cis-4-Amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidninyl]-2-methoxybenzamide;cis-4-amino-5-chloro-N-[1-[3-(p-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-o-anisamide.

Molecular formula

  • C23H29ClFN3O4.

Storage requirements

  • Store at room temperature.
  • Keep out of light and keep dry.

Uses

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Indications

  • Management of:
    • Esphageal reflux.
    • Gastric stasis.
    • Megacolon   Megacolon  .

    Cisapride has been withdrawn for use in humans in both the UK (July 2000) and USA. This decision follows reports of rare, but serious, ventricular arrhythmias (some fatal) suspected to be caused by the drug.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • Opioid analgesics and antimuscarinics (eg atropine   Atropine  ) may antagonize cisapride's effects.
  • Fatal arrhythmia may be seen in conjunction with:
    • Erythromycin, clarythromycin, troleandomycin.
    • Itraconazole, ketoconazole, fluconazole and micoconazole.
  • Increases bioavailability of ciclosporin.
  • Increases absorption of aspirin, acetaminophen, diazepam, ethanol.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • LeGrange S N, Boothe D M & Herndon Set al(1997)Pharmacokinetics and suggested oral dosing regime of cisapride - a study in healthy cats.JAAHA.33, 517-523.

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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