Felis ISSN 2398-2950

Cimetidine

Contributor(s): Lauren Trepanier

Introduction

Name

  • Cimetidine.

Class of drug

  • H2-antihistamine.

Description

Chemical name

  • N-cyano-N'-methyl-N"-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine.

Molecular formula

  • C10H16N6S.

Physical properties

  • Tablets.

Storage requirements

  • In a dry environment.

Uses

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Indications

  • Gastric and duodenal ulcers.
  • Uremic   Uremia  gastritis.
  • Stress or drug-related erosive gastritis.
  • Esophagitis   Esophagitis  .
  • Hypersecretory conditions secondary to gastrinoma or mastocytosis   Mastocytoma  .
  • Adjunctively to reverse metabolic alkalosis.
  • May be useful as an immunomodulating agent by preventing activation of suppressor T-cells by histamine, although evidence is lacking.

Administration

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Precautions

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Interactions

with other drugs

Drugs affected by cimetidine (increased plasma levels)

Sucralfate

  • Sucralfate may reduce bioavailability of H2 antagonists.
  • While there is little evidence to suggest that this is clinically significant it may be wise to administer sucralfate   Sucralfate  at least 30 minutes before cimetidine.

Antacids, digoxin, ketoconazole, metoclopropamide

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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