ISSN 2398-2950      

Chlorphenamine

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Synonym(s): Chlorpheniramine


Introduction

Name

  • Chlorphenamine.

Class of drug

  • H1 antihistamine.

Description

Chemical name

  • Gamma-(4-chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine.
  • 2-[p-chloro-alpha-(2-dimethylaminoethyl)benzyl]pyridine.

Molecular formula

  • C16H19ClN2.

Physical properties

  • Oily liquid.
  • 1 g soluble in 4 ml water.

Storage requirements

  • Injectable preparations should be stored in light resistant containers.

Uses

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Indications

  • Allergies.
  • Anaphylactic reactions.

Administration

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Pharmacokinetics

Precautions

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Interactions

with other drugs

  • CNS depressant drugs.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Paterson S (1995) Additive benefits of EFA's in dogs with atopic dermatitis after partial response to antihistamine therapy.  JSAP 36 (9), 389-394.
  • Scott D W & Miller W H Jr (1990) Nonsteroidal management of canine pruritis - chlorphenamine and a fatty acid supplement (DVM Derm Caps) in combination, and the fatty acid supplement at twice the manufacturer's recommended dosage. Cornell Vet 80 (4), 381-387.
  • Misawa M, Takenouchi K, Sato M & Yanaura S (1987) The effects of chlorphenamine and antiallergic drugs on Ascaris suum antigen-induced active cutaneous anaphylaxis in dogs. Jpn J Pharmacol 44 (1), 101-104.

Other sources of information

  • Based on Small Animal Formulary. Tennant B (1999) 3rd edn. BSAVA, UK.
  • Plumb D Veterinary Drug handbook. 3rd edn. pp 148-149.
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