ISSN 2398-2950      

Chloramphenicol

ffelis

Introduction

Name

  • Chloramphenicol.

Class of drug

  • Bacteriostatic antibiotic.
  • May be bactericidal at high concentrations.

Description

Chemical name

  • [R-(R*,R*)]-2,2-dichloro-N-[2-Hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide.

Molecular formula

  • C11H12Cl2N2O5.

Physical properties

  • Solution.
  • Tablets.

Storage requirements

  • Reconstituted sodium succinate injectable solution is stable for 30 days at room temperature and 6 months at -20°C.
  • Protect from light.

Uses

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Indications

Gram-positive infections

Gram-negative infections

Anaerobic infections

Other sensitive organisms

Administration

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Pharmacokinetics

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Precautions

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Interactions

with other drugs

Anticonvulsants (pentobarbital, phenobarbital, primidone and phenytoin)

  • Chloramphenicol is an irreversible inhibitor of hepatic cytochrome P450 dependent enzymes and so increases the plasma levels of these drugs Pentobarbital  Phenobarbital  Phenytoin  .
  • Recovery from the inhibitory effects requires synthesis of new liver enzymes and can take up to 3 weeks.

Iron salts and Vitamin B12

  • Decreased hematologic response may be seen Vitamin B12.

Rifampicin

  • Accelerates the metabolism of chloramphenicol, thus decreasing serum levels.

Adverse Reactions

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Further Reading

Publications

Refereed papers

Other sources of information

  • BSAVA Small Animal Formulary. Ramsey I (2017) 9th edn. BSAVA, UK.
MEMBER BENEFIT

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!

 
 
 
 

To show you are not a Bot please can you enter the number showing adjacent to this field

 Security code