Felis ISSN 2398-2950

Cefotaxime

Introduction

Name

  • Cefotaxime.

Class of drug

  • Third generation cephalosporin antibiotic.

Uses

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Indications

  • Many Gram-negative infections (notPseudomonasspp).
  • Use reserved for patients suffering from acute sepsis or serious infections where cultures are pending and the animal is not a good candidate for intensive aminoglycoside therapy (pre-existing renal dysfunction).
  • Cephalosporins are particularly useful for the treatment of susceptible renal infections.

Administration

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Pharmocokinetics

Precautions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Interactions

with other drugs

  • The bactericidal activity of cephalosporins may be affected by the concomitant use of bacteriostatic agents (eg tetracycline   Tetracycline  , erythromycin   Erythromycin  ).
  • There may be an increased risk of nephrotoxicity if cephalosporins are used with amphotericin   Amphotericin B  or loop diuretics; monitor renal function.
  • Probenecid reduces the excretion of cephalosporins.

Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

ADDED