Felis ISSN 2398-2950

Carprofen

Introduction

Name

  • Carprofen.

Class of drug

  • Non-steroidal anti-inflammatory (NSAID).

Uses

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Indications

  • Pain control and reduction of inflammation.
  • Analgesic activity enhanced if used pre-emptively.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • Carprofen is highly protein-bound and may displace other protein-bound drugs, thereby increasing the risk of toxicity.

Nephrotoxic agents

  • Avoid the concurrent use of NSAIDs with other potentially nephrotoxic agents, eg aminoglycosides.

Further Reading

Publications

Refereed papers

  • Al-Gizawiy M M & Rudé P E (2004)Comparison of preoperative carprofen and postoperative butorphanol as postsurgical analgesics in cats undergoing ovariohysterectomy.Vet Anaesth Analg.31(3), 164-174.DOI
  • Tomlinson J & Blikslager A (2003)Role of non-steroidal anti-inflammatory drugs in gastrointestinal tract injury and repair.JAVMA222(7), 946-951.PubMed
  • Halter F, Tarnawski AS, Schmassmann A & Peskar BM (2001)Cyclooxygenase 2-implications on maintenance of gastric mucosal integrity and ulcer healing: controversial issues and perspectives.Gut49(30), 443-453.PubMed
  • Firth A M & Haldane S L (1999)Development of a scale to evaluate post operative pain in dogs.JAVMA214(5), 651-659.PubMed
  • Isaacs J P (1999)Carprofen.Comp Contin Educ Pract Vet21(3) , 246-248.
  • Lascelles BDX, Cripps PJ, Jones A & Waterman-Pearson AE (1998)Efficacy and kinetics of carprofen, administered preoperatively or postoperatively, for the prevention of pain in dogs undergoing ovariohysterectomy.Vet Surg27(6), 568-582.PubMed
  • Balmer T & Curwen A (1997)Analgesia in cats.Vet Rec140, 435.PubMed
  • Mizuno H, Sakamoto, Matsuda Ket al(1997) Induction of cycooxygenase-2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice.Gastroenterology,112. 387-397.PubMed
  • David A & Simon A (1999)Use of Rimadyl in cats.Vet Rec 145.743. (Letter.)PubMed

Other sources of information

  • Pfizer, Inc.Five-year safety profile for Rimadyl (carprofen).2002
  • Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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