Felis ISSN 2398-2950

Carboplatin

Synonym(s): Paraplatin

Contributor(s): William Brewer Jr, Laura Garrett

Introduction

Name

  • Carboplatin.

Class of drug

  • Platinum compound antineoplastic agent.
  • Alkylating type agent.

Description

Chemical name

  • (SP-4-2)-Diammine[1,1-cyclobutanedicarboxylato(2-)-O,O']platinum; 1,1-cyclobutanedicarboxylic acid platinum complex.

Molecular formula

  • C6H12N2O4Pt.

Physical properties

  • White crystals.
  • Soluble in water.

Storage requirements

  • Room temperature and protected from light.
  • Reconstituted solutions at 1 mg/ml are stable for 24 hours at room temperature and 5 days in refrigerator.

Uses

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Indications

  • Used against various carcinomas and sarcomas.
  • Has been used in vaccine-associated sarcomas in cats   Feline injection-site associated sarcoma  .
  • Reported to increase the survival time when used as an adjunct to amputation in dogs with appendicular osteosarcoma. Seek specialist advice before use.

Administration

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Pharmocokinetics

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Precautions

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Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Rassnick K Met al(2001)Use of carboplatin for treatment of dogs with malignant melanoma- 27 cases (1989-2000).JAVMA218(9), 1444-1448.
  • Fox L E (2000)Carboplatin.JAAHA36(1), 13-4.
  • Hahn K Aet al(1997)Hematologic and systemic toxicoses associated with carboplatin administration in cats.Am J Vet Res58(6), 677-679.

Other sources of information

  • Fischer D S, Knobf M Tet al(2003)The Cancer Chemotherapy Handbook. 6th edn. Philadelphia, PA, Mosby. pp 234-236.
  • Plumb D C (2002)Veterinary Drug Handbook.4th edn. Ames, IA: Iowa State Press. pp 132-134.
  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA. ISBN: 0 9052 1452 8.
  • Theon A (1997)Intratumoral Chemotherapy in Small Animals.In:Proceedings of the 15th Annual Veterinary Medical Forum American College of Veterinary Internal Medicine.pp 180-181.

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