Felis ISSN 2398-2950

Cabergoline

Contributor(s): David Godfrey

Introduction

Name

  • Cabergoline.

Class of drug

  • Dopamine receptor agonist.

Description

Chemical name

  • 1-6-Allilergolin-8beta-ylcarbonyl-1-3-dimethylaminepropyl-3-ethylurea.

Molecular formula

  • Non-hormonal ergoline derivative.

Uses

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Indications

Dog
  • Treatment of pseudopregnancy   Pseudopregnancy  .
  • Suppression of milk production.
  • Adjunct in treatment of eclampsia and mastitis   Mastitis  .
  • Inducing abortion.
  • Reducing mammary tissue size in prolactin-dependent tumors   Mammary gland: neoplasia  .
  • Induction of estrus in the bitch   Failure to show estrus  .
  • May be used in conjunction with F2a prostaglandin analogue (eg dinoprost   Dinoprost trimethamine  ) to terminate unwanted pregnancy in the bitch. Pregnancy termination takes place by resorption of the fetuses.

Administration

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Pharmocokinetics

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Precautions

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Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Harvey MJA, Dale MJ, Lindley & Waterston MM (199)A study of the aetiology of pseudopregnancy in the bitch and the effect of cabergoline therapy.Vet. Rec.,144, 433-436.
  • Onclin K, Silva L D M, Donnay I and Verstegen J P (1999)Luteotrophic action of prolactin in dogs and the effects of a dopamine antagonist, cabergoline.J Reproduction and Fert Supl47, 403-409.
  • Jochle W & Jochle M (1993)Reproduction in a feral cat population and its control with a prolactin inhibitor, cabergoline.J Reprod Fertil Suppl.47, 419-424.

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