Felis ISSN 2398-2950

Avocado-soybean unsaponifiables

Synonym(s): ASU

Introduction

Name

  • Avocado/soybean unsaponifiables.

Class of drug

  • Nutraceutical.
  • Nutritional supplement.
  • Chondroprotective agent.

Description

Chemical name

  • Avocado/soybean unsaponifiables.

Molecular formula

  • Powder.

Storage requirements

  • Store in a cool, dry place.
  • Keep container tightly closed to ensure freshness.

Uses

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Indications

  • Management of degenerative joint disease/osteoarthritis   Arthritis: osteoarthritis  .
    • Slows damage to joint tissues.
    • Decreases lameness/pain.
  • Often used in combination with the nutraceutical agents glucosamine   Glucosamine   and chondroitin sulfate   Chondroitin sulfate  .

Administration

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Pharmocokinetics

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Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed.
  • Frondoza C G, Heinecke L F, Grzanna M Wet al(2011)Modulation of cytokine-induced prostaglandin E2 production in cultures of articular chondrocytes obtained from carpal joints of camels (Camelus dromedarius).Am J Vet Res72(1), 51-58PubMed.
  • Altinel L, Saritas Z K, Kose K Cet al(2007)Treatment with unsaponifiable extracts of avocado and soybean increases TGF-beta1 and TGF-beta2 levels in canine joint fluid.Tohoku J Exp Med211, 181-186PubMed.
  • Kawcak C E, Frisbie D D, McIlwraith C Wet al(2007)Evaluation of avocado and soybean unsaponifiable extracts for treatment of horses with experimentally induced osteoarthritis.Am J Vet Res68(6), 598-604PubMed.
  • Au R Y, al-Talib T K, Au A Yet al(2007)Avocado soybean unsaponifiables (ASU) suppress TNF-alpha, IL-1beta, COX-2, iNOS gene expression, and prostaglandin E2 and nitric oxide production in articular chondrocytes and monocyte/macrophages.Osteoarthritis Cartilage15, 1249-1255PubMed.

Other sources of information

  • Demko J L, Phan PV, Kramer E Aet al(2007)Inhibition of prostaglandin E-2 production in chondrocyte microcarrier spinner cultures by the combination of avocado soy unsaponifiables, chondroitin sulfate and glucosamine.Proceedings of the 34th Annual Conference of the Veterinary Orthopedic Society, 25.
  • Punke J P, Au A Y, Au R Yet al(2007)Modulation of prostaglandin E-2 production in feline articular chondrocytes propagated in monolayer and dynamic microcarrier culture.American College of Veterinary Surgeons Symposium, poster.
  • Au R Y, Au A Y, Cade Met al(2007)Down-regulation of pro-inflammatory markers in equine chondrocytes and osteoblasts by avocado soybean unsaponifiables, glucosamine, and chondroitin sulfate.American College of Veterinary Surgeons Symposium, poster.

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