Felis ISSN 2398-2950

Atropine

Synonym(s): Atropine sulfate

Contributor(s): Stephen Barr, Kyle Braund

Introduction

Name

  • Atropine

Class of drug

  • Parasympatholytic agent.

Description

Chemical name

  • Endo-(+/-)-alpha-(hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester.
  • 1-alphaH,5-alphaH-tropan-3-alpha-ol(+/-)-tropate (ester).

Molecular formula

  • C17H23NO3.

Physical properties

  • Clear, sterile solution.

Storage requirements

  • <25°C.
  • Protect from light.

Uses

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Indications

Administration

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Precautions

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Interactions

with other drugs

Drugs which may enhance the activity of atropine

The adverse effects of atropine may be potentiated by

  • Primidone Primidone.
  • Disopyramide Disopyramide.
  • Corticosteroids (prolonged use may increase intraocular pressure).

Drugs enhanced by atropine

  • Thiazide diuretics.
  • Sympathomimetics.

Drugs antagonized by atropine

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Brock KA (2001) Preanaesthetic use of atropine in small animalsAust Vet J 79(1), 24-25.

Other sources of information

  • Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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