Felis ISSN 2398-2950

Atipamezole

Contributor(s): Kyle Braund

Introduction

Name

  • Atipamezole.

Class of drug

  • Alpha-2 adrenoceptor antagonist.

Description

Chemical name

  • 4-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole.

Molecular formula

  • C14H16N2.

Physical properties

  • Colorless solution.

Storage requirements

  • <25°C.
  • Protect from light.

Uses

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Indications

  • Reversal of sedative effects of medetomidine.

Administration

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Precautions

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Interactions

with other drugs


Do not use in dogs when a combination of butorphanol, medetomidine and ketamine has been used.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from VetMed Resource and PubMed.
  • Cullen LK (1996) Medetomidine sedation in dogs and cats: a review of its pharmacology, antagonism and dose. Br Vet J.152(5), 519-535.
  • Stenberg D, Porkka-Heiskanen T & Toppila J (1993) Alpha 2-adrenoceptors and vigilance in cats: antagonism of medetomidine sedation by atipamezole. Eur J Pharmacol.238(2-3), 241-247.

Other sources of information

  • Based on Small Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.
  • Plumb DC (1999)Veterinary Drug Handbook. 3rd edn. Iowa State University Press, Ames. pp 62-63.

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