Felis ISSN 2398-2950
Atenolol
Contributor(s): Mark Rishniw
Introduction
Name
Class of drug
- Beta-1 adrenoceptor antagonist(beta blocker).
Description
Chemical name
- 4-[2'-hydroxy-3'-[(1-methylethyl)amino]propoxy]-benzeneacetamide.
Molecular weight
Physical properties
Uses
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Indications
Administration
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Pharmocokinetics
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Precautions
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Interactions
with other drugs
Sympathomimetics, eg epinephrine Epinephrine , phenylpropanolamine Phenylpropanolamine / diphenylpyraline , terbutaline Terbutaline
- May have their beta-effects blocked by atenolol.
- Thus, the unopposed alpha effects may result in severe hypertension and a decreased heart rate.
Anesthetic agents (those that depress myocardial activity), phenothiazines, antihypertensive drugs (eg hydralazine Hydralazine , prazosin), diazepam Diazepam , diuretics and other anti-arrhythmics
- Hypotensive effect of atenolol enhanced.
Calcium channel blockers, eg diltiazem Diltiazem , verapamil Verapamil
- There is an increased risk of bradycardia, severe hypotension, heart failure and AV block if used concurrently with atenolol.
Digoxin Digoxin
- Concurrent administration potentiates bradycardia.
Aluminum hydroxide
- Oral preparations reduce atenolol absorption.
Cimetidine Cimetidine
- May decrease the metabolism of atenolol, thereby increasing its blood levels.
Muscle relaxants, eg tubocurarine, suxamethonium Suxamethonium
- Effects enhanced by atenolol.
Phenobarbitone Phenobarbital , rifampin or phenytoin Phenytoin
- Hepatic enzyme induction by these drugs may increase the rate of metabolism of atenolol.
Insulin Insulin
- May prolong the hypoglycemic effects of insulin therapy.
Theophylline Theophylline
- The bronchodilatory effects may be blocked by atenolol.
Adverse Reactions
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Further Reading
Publications
Refereed papers
- Quinones Met al(1996)Pharmacokinetics of atenolol in clinically normal cats.AJVR57(7), 1050-1053.
Other sources of information
- Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.