Felis ISSN 2398-2950

Atenolol

Introduction

Name

• Atenolol.

Class of drug

• Beta-1 adrenoceptor antagonist(beta blocker).

Description

Chemical name

• 4-[2'-hydroxy-3'-[(1-methylethyl)amino]propoxy]-benzeneacetamide.

Molecular weight

• 266.

Physical properties

• H2O soluble.

Uses

Indications

• Cardiac arrhythmias
  • Atrial fibrillation .
  • Premature ventricular depolarization .
  • Supraventricular tachycardia .
• Hyperthyroidism   Hyperthyroidism  .
• Hypertrophic cardiomyopathy   Heart: hypertrophic cardiomyopathy  .
• Aortic stenosis   Heart: aortic stenosis  .
• Hypertension   Hypertension  .

Administration

Pharmacokinetics

Precautions

Interactions

with other drugs

• May have their beta-effects blocked by atenolol.
• Thus, the unopposed alpha effects may result in severe hypertension and a decreased heart rate.

Anesthetic agents (those that depress myocardial activity), phenothiazines, antihypertensive drugs (eg hydralazine  Hydralazine , prazosin), diazepam  Diazepam , diuretics and other anti-arrhythmics

• Hypotensive effect of atenolol enhanced.

Calcium channel blockers, eg diltiazem  Diltiazem , verapamil  Verapamil 

• There is an increased risk of bradycardia, severe hypotension, heart failure and AV block if used concurrently with atenolol.

Digoxin  Digoxin 

• Concurrent administration potentiates bradycardia.

Aluminum hydroxide

• Oral preparations reduce atenolol absorption.

Cimetidine  Cimetidine 

• May decrease the metabolism of atenolol, thereby increasing its blood levels.

Muscle relaxants, eg tubocurarine, suxamethonium  Suxamethonium 

• Effects enhanced by atenolol.

Phenobarbitone  Phenobarbital , rifampin or phenytoin  Phenytoin 

• Hepatic enzyme induction by these drugs may increase the rate of metabolism of atenolol.

Insulin  Insulin 

• May prolong the hypoglycemic effects of insulin therapy.

Theophylline  Theophylline 

• The bronchodilatory effects may be blocked by atenolol.

Adverse Reactions