Felis ISSN 2398-2950

Amphotericin B

Contributor(s): Sheryl Krohne

Introduction

Name

  • Amphotericin B.

Class of drug

  • Polyene antifungal antibiotic.

Description

Molecular formula

  • C47H73NO17.

Physical properties

  • Yellow powder/tablets or solution.

Storage requirements

  • Loss of drug activity is negligible for at least 8 hours in room light.
  • After reconstitution the preparation is stable for 1 week if refrigerated and stored in the dark.

Uses

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Indications

  • Serious systemic mycoses, eg cryptococcosis   Cryptococcosis  , histoplasmosis and blastomycosis.
  • Fungal septicemia.
  • Fungal urinary tract infections.
  • Candida  Candida albicans  (rare in cats) is particularly susceptible to this agent.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • Amphotericin may increase the toxic effects of cisplatin, fluorouracil, doxorubicin and methotrexate.
  • Flucytocine   Flucytosine  is synergistic with amphotericin Bin vitroversuscandida  Candida albicans  ,cryptococcus  Cryptococcosis  andaspergillosis  Aspergillosis  .

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.
  • Plumb D (1999)Veterinary Drug Handbook.3rd Edn. Iowa State University Press.

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