Felis ISSN 2398-2950

Amlodipine

Contributor(s): Esther Bijsmans

Introduction

Name

  • Amlodipine besylate.

Class of drug

  • Third generation dihydropyridine .
  • Calcium-channel blocker.

Description

Chemical name

  • (RS)-3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate.

Molecular formula

  • C20H25ClN2O5

Molecular weight

  • 408.879

Storage requirements

  • Amodip 1.25 mg chewable tablets for cats:
    • Do not store above 30°C.
    • Shelf life of the veterinary medicinal product as packaged for sale: 30 months.
    • Shelf life of halved tablets: 24 hours.
    • Any unused half tablets should be returned to the blister pack.

Uses

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Indications

Administration

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Pharmocokinetics

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Precautions

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Interactions

with diagnostic tests

  • Successful antihypertensive treatment with amlodipine is associated with a decrease in urine protein:creatinine ratios. Ventricular hypertrophy (diagnosed by echocardiography) may resolve after the initiation of amlodipine.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from VetMed Resource and PubMed.
  • Huhtinen M, Derr√© G, Renoldi H Jet al(2015)Randomized placebo-controlled clinical trial of a chewable formulation of amlodipine for the treatment of hypertension in client-owned cats.J Vet Intern Med29(3), 786-793PubMed.
  • Helms S R (2007)Treatment of Feline Hypertension With Transdermal Amlodipine: A Pilot Study.JAAHA43(3), 149-156PubMed.
  • Jepson R E, Elliott J, Brodbeld D, Syme H M (2007)Effect of control of systolic blood pressure on survival in cats with systemic hypertension.J Vet Intern Med21, 402-409PubMed.
  • Snyder P S, Sadek D, Jones G L (2001)Effect of amlodipine on echocardiographic variables in cats with systemic hypertension.J Vet Intern Med15(1), 52-56PubMed.
  • Elliott J, Barber PJ, Syme H M, Rawlings J M & Markwell P J (2001)Feline hypertension: clinical findings and response to antihypertensive treatment in 30 cases.J Small Anim Pract.42(3), 122-129PubMed.
  • Snyder P S (1998)Amlodipine: a randomized, blinded, clinical trial in 9 cats with systemic hypertension.J Vet Intern Med12,157-162PubMed.

Other sources of information

  • Bijsmans E S, Jepson R E, Syme H M, Elliott J, Pelligand L (2015)Measurement of plasma amlodipine concentration using LC/MS/MS at the point of blood pressure control in hypertensive cats (abstract).J Vet Intern Med29(4), 1224 (ACVIM Forum Abstract).
  • Small Animal Formulary. Tennant, Bryn (2014) 8th edn. Cheltenham: BSAVA.
  • Bijsmans E S, Jepson R E, Syme H M, Elliott J (2014)The efficacy of amlodipine besylate to control hypertension in cats with CKD (abstract).BSAVA Congress Proceedings.

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