Felis ISSN 2398-2950

Amitryptiline

Contributor(s): Rosanna Marsella

Introduction

Name

  • Amitryptiline.

Class of drug

  • Tricyclic antidepressant.

Description

Physical properties

  • Soluble in water and alcohol.
  • Bitter taste.

Uses

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Indications

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

Anesthetics and antidysrhythmics
  • Increased risk of dysrhythmias.

Anti-epileptics

  • Antagonizes the effects of anti-epileptics.
  • Cimetidine   →   reduces metabolism of amitriptiline   →   increased concentration of amitriptiline.

Sedatives

  • Increases sedative effect if used with other sedative drugs.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Scott D W & Miller W H Jr (1993)Nonsteroidal anti-inflammatory agents in the management of canine allergic pruritus.J S Afr Vet Assoc64(1), 52-56.
  • Miller W H Jr, Scott D W & Wellington J R (1992)Nonsteroidal management of canine pruritus with amitriptiline.Cornell Vet82(1), 53-57.
  • Friehe H & Fontaine R (1978)Toxicology of amitriptilinoxide.Arzneimittelforschung28(10b), 1898-1907.

Other sources of information

  • Based on Tennant B (1999)Small Animal Formulary.3rd edn. Cheltenham: BSAVA.
  • Plumb DVeterinary Drug handbook.3rd edn. pp 34-36.

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