Felis ISSN 2398-2950

Amitryptiline

Contributor(s): Rosanna Marsella, Vetstream Ltd

Introduction

Name

  • Amitryptiline.

Class of drug

  • Tricyclic antidepressant.

Description

Physical properties

  • Soluble in water and alcohol.
  • Bitter taste.

Uses

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Indications

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Anesthetics and antidysrhythmics

  • Increased risk of dysrhythmias.

Anti-epileptics

  • Antagonizes the effects of anti-epileptics.
  • Cimetidine   →   reduces metabolism of amitriptiline   →   increased concentration of amitriptiline.

Sedatives

  • Increases sedative effect if used with other sedative drugs.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMed Resource.
  • Scott D W & Miller W H Jr (1993) Nonsteroidal anti-inflammatory agents in the management of canine allergic pruritus. J S Afr Vet Assoc 64(1), 52-56.
  • Miller W H Jr, Scott D W & Wellington J R (1992) Nonsteroidal management of canine pruritus with amitriptiline. Cornell Vet 82(1), 53-57.
  • Friehe H & Fontaine R (1978) Toxicology of amitriptilinoxide. Arzneimittelforschung 28(10b), 1898-1907.

Other sources of information

  • Based on Tennant B (1999) Small Animal Formulary. 3rd edn. Cheltenham: BSAVA.
  • Plumb D Veterinary Drug handbook. 3rd edn. pp 34-36.

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