Felis ISSN 2398-2950

Amikacin

Introduction

Name

  • Amikacin.

Class of drug

  • Aminoglycoside antibiotic.

Uses

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Indications

  • Gram-negative infections, includingPseudomonasspp.
  • Ineffective against anaerobes.
  • Some efficacy againstStaphylococcusspp.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • Avoid the concurrent use of other nephrotoxic, ototoxic or neurotoxic agents (eg amphotericin B, cisplatin, furosemide, methoxyflurane, NSAIDs).
  • Aminoglycosides may be inactivated by beta-lactam antibiotics (eg penicillins, cephalosporins or heparin) when mixedin vitro. This may present a problemin vivoin patients who have substantially diminished renal function.
  • The effect of non-depolarizing muscle relaxants (eg atracurium, pancuronium, tubocuramine, vecuronium) may be enhanced by aminoglycosides.
  • Synergism may occur when aminoglycosides are used with penicillins or cephalosporins(Streptococcus faecalis)or with ticarcillin   Ticarcillin  (Pseudomonas aeruginosa).

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA ISBN: 0 905214 44 7.

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