Felis ISSN 2398-2950

Alfentanil

Contributor(s): John Dodam

Introduction

Name

  • BANM

Class of drug

  • Analgesics (mu opioid agonist).

Description

Chemical name

  • Alfentanil hydrochloride.

Molecular formula

  • 4-anilinopipridine analogue.

Physical properties

  • Water soluble.
  • Lipid soluble
  • pKa - 6.8.

Uses

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Indications

Analgesia/Profound sedation

  • EitherAlone for very short procedures, eg radiotherapy.
    Or used in conjunction with other anesthetics as part of a balanced anesthesia protocol.
    • Augments intraoperative analgesia.
    • Decreases the amount of other anesthetics that must be used.

Ophthalmic anesthesia

  • Improved reduction in intraocular pressure compared to fentanyl with similar cardiac stability.
    Potent respiratory depressant. Must have facilities for tracheal intubation and IPPV.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • Reduces MAC of halothane by almost 50%.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Clinical Anaesthetic Pharmacology, Editors: John W Dundee, R.S.J.Clarke, William McCaughey. Pub: Churchill Livingstone. 1991.
  • Martindale: The Extra Pharmacopoeia The London Pharmaceutical Society. 31st Edition.
  • Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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