Felis ISSN 2398-2950

Aglepristone

Synonym(s): RU 534

Contributor(s): Monica Ptaszynska

Introduction

Name

  • Aglepristone.

Class of drug

  • Progesterone receptor antagonist.

Description

Chemical name

  • (8S,11R,13S,14S,17R)-11-(4-dimethylaminophenyl)-17-hydroxy-13-methyl-17-[(Z)-prop-1-enyl]-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one

Molecular formula

  • C29H37NO2

Molecular weight

  • 431.60958

Physical properties

  • Clear yellow oily solution.

Storage requirements

  • Shelf life of 3 years.
  • Once opened must be used within 28 days and discarded if discoloration occurs.
  • As the available veterinary formulation contains no antibacterial preservative, swab the opening's membrane with suitable disinfectant each time before withdrawing the dose to be administered.
  • Protect the bottle from light.

Uses

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Indications

  • Pregnancy termination in female dogs.
    Not licensed for use in the cat.
  • Literature evidence indicates high efficacy for pregnancy termination in female cats when administered between 5 and 30 days of mating and lower efficacy when used before the end of estrus or after 45 d of pregnancy.
  • Literature evidence indicates that aglepristone is efficacious as a treatment of progestagen-dependent mammary fibroadenomatous hyperplasia (fibroadenomatosis) in queens   Mammary hyperplasia  .

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • No data on interaction with other drugs in cats is available, however in dogs it is recommended to avoid the use with ketoconazole   Ketoconazole  , itraconazole   Itraconazole   and erythromycin   Erythromycin   as interaction may occur. In dogs, aglepristone may reduce the effect of glucocorticoid treatment.

with diagnostic tests

  • No data is available on the effect of the treatment on basic hematological and metabolic indices in cats. Hematological and biochemical changes (urea, creatinine, chloride, potassium, sodium, ALT, ALP, AST) reported in up to 5% of dogs following injection   Blood biochemistry: overview  .

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed.
  • Georgiev P, Bostedt H, Goericke-Pesch S, Dimitrov M, Petkov P, Stojanthev K, Tsoneva V, Wehrend A (2010)Induction of abortion with aglepristone in cats on day 45 and 46 after mating.Reprod Domest Anim45(5), e161-167PubMed.
  • Goericke-Pesch S, Plamen,  Georgiev P (2010)Prevention of pregnancy in cats using aglepristone on days 5 and 6 after mating.Theriogenology74(2), 304-310PubMed.
  • Jurka P, Max A (2009)Treatment of fibroadenomatosis in 14 cats with aglepristone - changes in blood parameters and follow-up.Vet Rec165(22), 657-660PubMed.
  • Nak D, Nak Y, Tuna B (2009)Follow-up examinations after medical treatment of pyometra in cats with the progesterone-antagonist aglepristone.JFMS11(6), 499-502PubMed.
  • Favre R N, Gimenez F, Stornelli M C, Tittarelli C M, Savignone C A, de la Sota R L, Sternelli M A (2007)Induction of abortion in queens by administration of aglepristone (Alizin): Preliminary results. Theriogenology68, 492-518; abstr.014.
  • Fieni F, Martal J, Marnet P G, Siliart B, Guittot F (2006)Clinical, biological and hormonal study of mid-pregnancy termination in cats with aglepristone.Theriogenology66(6-7), 1721-1728. Epub 2006 Mar 24. Erratum in:Theriogenology67(7), 1305PubMed.
  • Georgiev P, Wehrend A (2006)Mid-gestation pregnancy termination by the progesterone antagonist aglepristone in queens.Theriogenology65(7), 1401-1406PubMed.
  • Georgiev P, Wehrend A, Dimitrov M, Vasilev N, Yotov S, Bostedt H (2006) Effect of progesterone receptor antagaonist aglepristone administered on days 5 and 6 after mating in queens.Reprod Domest Anim41(Suppl 1), 1-41 (abstr).
  • Meisl D, Hubler M, Arnols S (2003)Treatment of fibroepithelial hyperplasia (FEH) of the mammary gland in the cat with progesterone antagonist aglepristone (Alizine).Schweiz Arch Tierheilkd145(3), 130-136PubMed.
  • Goerlinger S, Kooistra H S, van den Broek A, Okkens A C (2002)Treatment of fibroadenomatous hyperplasia in cats with aglepristone.J Vet Intern Med16(6), 710-713.
  • Wehrend A, Hospes R, Gruber A D (2001)Treatment of feline mammary fibroadenomatous hyperplasia with a progesterone-antagonist.Vet Rec148(11), 346-347PubMed.

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