Felis ISSN 2398-2950

Acetazolamide

Contributor(s): Sheryl Krohne

Introduction

Name

  • Acetazolamide.

Class of drug

  • Carbonic anhydrase inhibitor.

Description

Chemical name

  • N-[5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl]acetamide.
  • 5-acetamido-1,3,4-thiadiazole-2-sulfonamide.

Molecular formula

  • C4H6N4O3S2.

Storage requirements

  • Store at room temperature.
  • After reconstitution: injection is stable for one week when refrigerated - use within 24 h without preservative.

Uses

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Indications

  • Acetazolamide is a carbonic anhydrase inhibitor diuretic which is primarily used for the treatment of acute glaucoma   Glaucoma   and as long-term medical control of glaucoma in visual eyes.
  • It reduces the production of bicarbonate in aqueous humour and the water secreted with it, thus lowering intraocular pressure.

Administration

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Precautions

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Interactions

with other drugs

  • Primidone   Primidone   absorption may be inhibited by oral acetazolamide.
  • Acetazolamide alkalinizes urine, thus the excretion rate of weak bases may be decreased, but weak acids increased.
  • Concomitant use of corticosteroids may exacerbate potassium depletion causing hypokalemia   Blood biochemistry: potassium  .

Adverse Reactions

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Further Reading

Publications

Referred papers

Other sources of information

  • Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.
  • Plumb D (1999) Veterinary Drug Handbook. 3rd Edn. Iowa State University Press.

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