Felis ISSN 2398-2950

Acepromazine maleate

Synonym(s): ACP, acetylpromazine

Contributor(s): Kyle Braund

Introduction

Name

  • Acepromazine maleate.

Class of drug

  • Phenothiazine.

Description

Chemical name

  • 1-[10-[3-(dimethylamino)propyl]-10H-phenothiazin-2-yl-ethanone.
  • 10-[3-(dimethylamino)propyl]phenothiazin-2-yl methyl ketone.

Molecular formula

  • C19H22N2OS.C4H4O4.

Physical properties

  • Pale yellow solution or tablets.

Storage requirements

  • <25°C.
  • Protect from light.

Uses

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Indications

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • Other central nervous system (CNS) depressant agents (barbiturates Pentobarbital, narcotics, anesthetics) may cause additive CNS depression if used with acepromazine.
  • Quinidine when given with phenothiazines may cause additive cardiac depression.
  • Antidiarrheal mixtures, eg kaolin/pectin Kaolin, bismuth subsalicylate and antacids may cause reduced gastrointestinal (GI) absorption of oral phenothiazines.
  • Increased blood levels of both drugs may result if propranolol Propranolol is administered with phenothiazines.
  • As phenothiazines block alpha-adrenergic receptors, concomitant use with epinephrine Epinephrine may lead to unopposed beta activity, thereby causing vasodilation and tachycardia.
  • Phenytoin Phenytoin metabolism may be decreased if given concurrently with phenothiazines.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Pereira G G et al (2004) Effects of propofol on the electrocardiogram and systolic blood pressure of healthy cats pre-medicated with acepromazine.Vet Anaesth Analg 31(3), 235-238 DOI.
  • Hall T L, Duke T, Townsend H G, Caulkett N A & Cantwell S L (1999) The effect of opioid and acepromazine premedication on the anesthetic induction dose of propofol in catsCan Vet J 40(12), 867-870.
  • Briggs S L, Sneed K & Sawyer D C (1998) Antinociceptive effects of oxymorphone-butorphanol-acepromazine combination in cats. Vet Surg 27(5), 466-472.

Other sources of information

  • Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.
  • Plumb DC (1999) Veterinary Drug Handbook. 3rd edn. Iowa State University Press, Ames. pp 1-3

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