ISSN 2398-2950      

Acepromazine maleate

ffelis
Contributor(s):

Kyle Braund

Vetstream Ltd

Synonym(s): ACP, acetylpromazine


Introduction

Name

  • Acepromazine maleate.

Class of drug

  • Phenothiazine.

Description

Chemical name

  • 1-[10-[3-(dimethylamino)propyl]-10H-phenothiazin-2-yl-ethanone.
  • 10-[3-(dimethylamino)propyl]phenothiazin-2-yl methyl ketone.

Molecular formula

  • C19H22N2OS.C4H4O4.

Physical properties

  • Pale yellow solution or tablets.

Storage requirements

  • <25°C.
  • Protect from light.

Uses

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Indications

Administration

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Pharmacokinetics

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Precautions

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Interactions

with other drugs

  • Other central nervous system (CNS) depressant agents (barbiturates Pentobarbital, narcotics, anesthetics) may cause additive CNS depression if used with acepromazine.
  • Quinidine when given with phenothiazines may cause additive cardiac depression.
  • Antidiarrheal mixtures, eg kaolin/pectin Kaolin, bismuth subsalicylate and antacids may cause reduced gastrointestinal (GI) absorption of oral phenothiazines.
  • Increased blood levels of both drugs may result if propranolol Propranolol is administered with phenothiazines.
  • As phenothiazines block alpha-adrenergic receptors, concomitant use with epinephrine Epinephrine may lead to unopposed beta activity, thereby causing vasodilation and tachycardia.
  • Phenytoin Phenytoin metabolism may be decreased if given concurrently with phenothiazines.

Adverse Reactions

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Pereira G G et al (2004) Effects of propofol on the electrocardiogram and systolic blood pressure of healthy cats pre-medicated with acepromazine.Vet Anaesth Analg 31 (3), 235-238 DOI.
  • Hall T L, Duke T, Townsend H G, Caulkett N A & Cantwell S L (1999) The effect of opioid and acepromazine premedication on the anesthetic induction dose of propofol in catsCan Vet J 40 (12), 867-870.
  • Briggs S L, Sneed K & Sawyer D C (1998) Antinociceptive effects of oxymorphone-butorphanol-acepromazine combination in cats. Vet Surg 27 (5), 466-472.

Other sources of information

  • Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. BSAVA, USA.
  • Plumb D C (1999) Veterinary Drug Handbook. 3rd edn. Iowa State University Press, USA. pp 1-3.
MEMBER BENEFIT

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!

 
 
 
 

To show you are not a Bot please can you enter the number showing adjacent to this field

 Security code