Felis ISSN 2398-2950

Therapeutics: oral chondroprotectants

Synonym(s): Chondromodulating drugs, nutraceuticals

Contributor(s): Brian Beale, David Godfrey, John J Haburjak, Lauren Trepanier


  • Classified as:
    • Slow-acting drugs in osteoarthritis (SADOA).
      • Symptomatic slow-acting drugs in osteoarthritis   Arthritis: osteoarthritis   (SYSADOA).
      • Disease-modifying osteoarthritis drugs (DMOAD).
    • Chondromodulating drugs.
    • Nutraceuticals   Nutraceuticals: principles and uses   (glucosamines, chondroitin sulfate, ASU) .
      Unity in quality, grade and quantity (strength) cannot be guaranteed or easily verified for nutraceuticals.
      Equivalency between different product labels is not easily compared.
      Nutraceuticals cannot be sold with the claim of efficacy in the treatment of osteoarthritis.


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Omega-3 fatty acids

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Further Reading


Refereed papers
  • Recent references fromPubMed.
  • Bauer J E (2012)Therapeutic use of fish oils in companion animals. JAVMA239(11), 1441-1451PubMed.
  • Au R Y, al-Talib T K, Au A Y, Phan P V & Frondoza C G (2007)Avocado soybean unsaponifiables (ASU) suppress TNF-alpha. IL-1beta, COX-2, iNOS gene expression, and postaglandin E2 and nitric oxide production in articular chondrocytes and monocyte/macrophages. Osteoarthritis Cartilage15, 1249-1255PubMed.
  • Beale B S (2004)Use of nutraceuticals and chondroprotectants in osteoarthritic dogs and cats. Vet Clin North Am Small Anim Pract34(1), 271-284PubMed.
  • Davidson G. (2000)Glucosamine and chondroitin sulfate. Compend Contin Educ Pract Vet  1,454-458.
  • Anderson M A (1999)Oral Chondroprotectants. Part I. Compend Contin Educ Pract Vet 21,601-609.
  • Anderson M A (1999)Oral Chondroprotectants.Part II  Compend Contin Educ Pract Vet 21, 861-865.
  • McNamara P S, Johnston S A & Todhunter R J (1997)Slow-acting disease-modifying osteoarthritis agents. Vet Clin N Amer Sm Anim Pract 27,863-881. Review PubMed.

Other sources of information

  • Punke J P, Au R Y, Au A Y, Phan P, Budsberg S C & Frondoza C G (2007)Modulation of prostaglandin E-2 production in feline articular chondrocytes propagated in monolayer and dynamic microcarrier culture.American College of Veterinary Surgeons Veterinary Symposium; poster.
  • Plumb D C (Ed.)Veterinary Drug Handbook.3rd edn. Iowa State Press, Ames.