Felis ISSN 2398-2950

Perioperative complications: drug interactions

Contributor(s): Graham Bilbrough, John Dodam, Lauren Trepanier

Introduction

  • Polypharmacy (using multiple drugs at the same time in the same patient) is sometimes unavoidable in patients with multiple acute or chronic medical problems, particularly in the perioperative period. However, the risk of drug interactions (and adverse effects) multiplies as the number of administered drugs increases.
  • Interactions can occur during:
    • IV drug administration.
    • Oral absorption, at the target site (either antagonistic or synergistic effects).
    • Hepatic or renal elimination.
  • Any of these interactions may lead to loss of efficacy or increased risk of toxicity.
  • Although virtually all of knowledge of drug interactions is from data in humans, many of these interactions are also likely to occur in veterinary patients.

The top potential offenders for drug interactions in the perioperative period

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Further Reading

Publications

Refereed papers

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