Felis ISSN 2398-2950

Inflammatory bowel disease: overview

Synonym(s): IBD

Contributor(s): Julien Bazelle, Ed Hall, Kenneth Simpson

Introduction

  • Most common cause of chronic vomiting Vomiting and diarrhea Diarrhea: overview.
  • Cause: any idiopathic inflammatory condition of the small or large intestine:
  • Signs: chronic gastroenteritis (diarrhea and vomiting), weight loss.
  • Characterized by infiltration of gastrointestinal tract with inflammatory cells including:
    • Lymphocytes.
    • Plasma cells.
    • Eosinophils.
    • Macrophages.
    • Neutrophils.
  • Diagnosis: idiopathic nature makes it a diagnosis of exclusion.
  • Treatment: dietary change, immunosuppressive therapy (prednisolone/azathioprine/chlorambucil).
  • Prognosis: good with appropriate treatment.
    Print off the owner factsheet on Inflammatory bowel disease  Inflammatory bowel disease  to give to your client.

Pathogenesis

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Signs

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Diagnosis

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Differential diagnosis

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Treatment

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Further Reading

Publications

Refereed papers

  • Recent references from VetMed Resource and PubMed.
  • Lalor S, Schwartz A M, Titmarsh H, Reed N, Tasker S, Boland L, Berry J, Gunn-Moore D, Mellanby R J (2014) Cats with inflammatory bowel disease and intestinal small cell lymphoma have low serum concentrations of 25-hydroxyvitamin D. JVIM 28, 351-355 PubMed.
  • Burke K F, Broussard J D, Ruaux C G, Suchodolski J S, Williams D A & Steiner J  M (2013) Evaluation of fecal alpha1-proteinase inhibitor concentrations in cats with idiopathic inflammatory bowel disease and cats with gastrointestinal neoplasia. Vet J 196, 189-196 PubMed.
  • Kiupel M, Smedley R C, Pfent C, Xie Y, Xue Y, Wise A G, DeVaul J M & Maes R K (2011) Diagnostic algorithm to differentiate lymphoma from inflammation in feline small intestinal biopsy samples. Vet Pathol 48, 212-222 PubMed.
  • Scott K D, Zoran D L, Mansell J, Norby B & Willard M D (2011) Utility of endoscopic biopsies of the duodenum and ileum for diagnosis of inflammatory bowel disease and small cell lymphoma in cats. JVIM 25, 1253-1257 PubMed.
  • Bailey S, Benigni L, Eastwood J, Garden O A, McMahon L, Smith K, Steiner J M, Suchodolski J S & Allenspach K (2010) Comparisons between cats with normal and increased fPLI concentrations in cats diagnosed with inflammatory bowel disease. JSAP 51, 484-489 PubMed.
  • Jergens A E, Crandell J M, Evans R, Ackermann M, Miles K G & Wang C (2010) A clinical index for disease activity in cats with chronic enteropathy. JVIM 24, 1027-1033 PubMed.
  • Zwingenberger A L, Marks S L, Baker T W & Moore P F (2010) Ultrasonographic evaluation of the muscularis propria in cats with diffuse small intestinal lymphoma or inflammatory bowel disease. JVIM 24, 289-292 PubMed.
  • Trepanier L (2009) Idiopathic inflammatory bowel disease in cats.  Rational treatment selection. J Feline Med Surg 11, 32-38 PubMed.
  • Sturgess K (2005) Diagnosis and management of idiopathic inflammatory bowel disease in dogs and cats. In Practice 27, 293-301.
  • Guilford et al(2001) Food sensitivity in cats with chronic idiopathic GI problems. JVIM 15, 7-13 PubMed.
  • Simpson K et al(2001) Subnormal concentrations of cobalamin in cats with GI disease. JVIM 15, 26-32 PubMed.
  • Baez J L et al(1999 )Radiographic, ultrasonographic, and endoscopic findings in cats with inflammatory bowel disease of the stomach and small intestine - 33 cases (1990-1997). JAVMA 215(3), 349-354 PubMed.
  • Willard M D (1999) Feline inflammatory bowel disease: A review. J Feline Med Surg 1(3), 155-164 PubMed
  • Weiss D J, Gagne J M & Armstrong P J (1996) Relationship between inflammatory hepatic disease and inflammatory bowel disease, pancreatitis and nephritis in cats. JAVMA 209, 1114-1116 PubMed.
  • Hart J R, Shaker E, Patnaik A K et al(1994) Lymphocytic-plasmocytic enterocolitis in cats; 60 cases (1988-1990). JAVMA 30, 505-514.
  • Tams R (1993 )Feline inflammatory bowel disease. Vet Clin North Am 23, 569-586 PubMed.
  • Jergens A E, Moore F M & Haynes J S (1992) Idiopathic inflammatory bowel disease in dogs and cats; 84 cases (1987-1990). JAVMA 201, 1603-1608 PubMed.


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