ISSN 2398-2950      

Stomach: chronic gastritis

ffelis

Introduction

  • Chronic signs of gastric disease, with concurrent chronic inflammatory changes in gastric mucosa. 
  • Cause: damage to gastric mucosal barrier allows back-diffusion of acid leading to further mucosal damage.
  • Signs: vomiting.
  • Diagnosis: histopathology (gastric mucosa).
  • Treatment: eliminate underlying cause, dietary manipulation, antacid therapy, anti-emetics.
  • Prognosis: good if underlying cause treated.

Pathogenesis

Etiology

Pathophysiology

  • Damage to gastric mucosal barrier   →   allows back-diffusion of gastric acid and pepsin   →   local inflammation extending deeper   →   degranulation of enterochromaffin-like cells in submucosa and lamina propria   →   histamine stimulates further production of hydrochloric acid   →   further mucosal damage.

Timecourse

  • Months.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Marks S L, Kook P H, Papich M G, Tolbert M K, Willard M D (2018) ACVIM consensus statement: Support for rational administration of gastrointestinal protectants to dogs and cats. JVIM 32(6), 1823-1840 PubMed  Full Article.
  • Neiger R & Simpson K W (2000) Helicobacter infection in dogs and cats: facts and fiction. JVIM 14 (2), 125-133 PubMed.

Other sources of information

  • Burrows C F (1996) Gastric disease. In: Manual of Canine and Feline Gastroenterology. BSAVA, Cheltenham. pp 90-113.

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