ISSN 2398-2950      

Sacrocaudal dysgenesis of Manx cats

ffelis
Contributor(s):

Kyle Braund

Laurent Garosi

Synonym(s): Caudal dysgenesis


Introduction

  • Cause: inherited abnormality in Manx cats.
  • Signs: paraplegia, incontinence, abnormal gait.
  • Diagnosis: signs, radiography.
  • Treatment: symptomatic.
  • Prognosis: poor.

Pathogenesis

Pathophysiology

  • Autosomal dominant inheritance occurs with incomplete penetrance.
  • Most Manx cats have abnormal sacrum and spinal cord.
  • Dysgenesis of sacral or caudal vertebrae   →   spina bifida Spina bifida or abnormalities of terminal spinal cord   →   neurological deficits.
  • May be associated with:
    • Myelodysplasia.
    • Meningocele.
    • Duplication of spinal cord.
    • Clefting of spinal cord.
    • Syringomyelia.
    • Subcutaneous cyst formation.

Timecourse

  • Signs apparent soon after birth.
  • May be progressive or static.

Diagnosis

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Treatment

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Prevention

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Westworth D R, Sturges B K (2010) Congenital spinal malformations in small animals. Vet Clin Small Anim 40 (5), 951-981 PubMed.
  • Newitt A , German A J, Barr F J (2008) Congenital abnormalities of the feline vertebral column. Vet Radiol Ultrasound 49 (1), 35-41 PubMed.
  • Robinson R (1993) Expressivity of the Manx gene in cats. J Hered 84 (3), 170-172 PubMed.
  • Woodside J R, Dail W G, McGuire E J et al (1982) The Manx cat as an animal model for neurogenic vesical dysfunction associated with myelodysplasia: a preliminary report. J Urol 127 (1), 180-183 PubMed.
  • Deforest M E & Basrur P K (1979) Malformations and the Manx syndrome in cats. Can Vet J 20 (11), 304-314 PubMed.
  • James C C, Lassman L P & Tomlinson B E (1969) Congenital anomalies of the lower spine and spinal cord in Manx cats. J Pathol 97 (2), 269-276 PubMed.

Other sources of information

  • Braund K G (2002) Developmental Disorders. In: Clinical Neurology in Small Animals - Localization, Diagnosis and Treatment. Ed K G Braund. Ithaca: International Veterinary Information Service. Document no B0217. 0202.

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