Felis ISSN 2398-2950

Plasmacytoma

Synonym(s): plasma cell tumour, extramedullary plasmacytoma, plasma cell tumor

Contributor(s): William Brewer Jr, Jo Morris

Introduction

  • Extremely rare - not reported in cat as distinct tumor separate from plasma cell myeloma.
  • Only two possible cases documented in the literature and both had monoclonal gammopathy.
  • Both cases negative Feline Leukemia Virus (FeLV) status.
  • Cause: neoplastic proliferation of plasma cells.
  • Signs: skin mass, vague signs of illness.
  • Diagnosis: histopathology on biopsy.
  • Treatment: surgical excision, chemotherapy, radiotherapy.
  • Prognosis: poor. Solitary extramedullary plasmacytoma in dogs have been cured by surgical excision.

Pathogenesis

Pathophysiology

  • Proliferation of neoplastic plasma cells at a site distant from the bone marrow   →   production of excess immunoglobulin   →   hyperviscosity and possibly amyloidosis.
  • Solitary proliferation of neoplastic plasma cells at a site distant from bone marrow   →   production of excess immunoglobulin (IgG or IgA reported in cats) by neoplastic cells.
  • Hyperglobulinemia   →   hyperviscosity and bleeding disorders.
  • May cause amyloid deposits associated with tumor site (primary amyloidosis Amyloidosis).
  • Neoplastic cells may spread to local lymph nodes and distant sites - spleen and liver.
  • If bone marrow involvement is found the diagnosis is multiple myeloma.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Ward D A, McEntee M F & Weddle D L (1997) Orbital plasmacytoma in a cat. JSAP 38 (12), 576-578 PubMed.
  • Carothers M A, Johnson G C, DiBartola S P et al (1989) Extramedullary plasmacytoma and immunoglobulin-associated amyloidosis in a cat. JAVMA 195 (11), 1593-1597 PubMed.


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