ISSN 2398-2950      

Plasmacytoma

ffelis

Synonym(s): plasma cell tumour, extramedullary plasmacytoma, plasma cell tumor


Introduction

  • Extremely rare - not reported in cat as distinct tumor separate from plasma cell myeloma.
  • Only two possible cases documented in the literature and both had monoclonal gammopathy.
  • Both cases negative Feline Leukemia Virus (FeLV) status.
  • Cause: neoplastic proliferation of plasma cells.
  • Signs: skin mass, vague signs of illness.
  • Diagnosis: histopathology on biopsy.
  • Treatment: surgical excision, chemotherapy, radiotherapy.
  • Prognosis: poor. Solitary extramedullary plasmacytoma in dogs have been cured by surgical excision.

Pathogenesis

Pathophysiology

  • Proliferation of neoplastic plasma cells at a site distant from the bone marrow   →   production of excess immunoglobulin   →   hyperviscosity and possibly amyloidosis.
  • Solitary proliferation of neoplastic plasma cells at a site distant from bone marrow   →   production of excess immunoglobulin (IgG or IgA reported in cats) by neoplastic cells.
  • Hyperglobulinemia   →   hyperviscosity and bleeding disorders.
  • May cause amyloid deposits associated with tumor site (primary amyloidosis Amyloidosis).
  • Neoplastic cells may spread to local lymph nodes and distant sites - spleen and liver.
  • If bone marrow involvement is found the diagnosis is multiple myeloma.

Diagnosis

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Treatment

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Outcomes

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Ward D A, McEntee M F & Weddle D L (1997) Orbital plasmacytoma in a cat. JSAP 38 (12), 576-578 PubMed.
  • Carothers M A, Johnson G C, DiBartola S P et al (1989) Extramedullary plasmacytoma and immunoglobulin-associated amyloidosis in a cat. JAVMA 195 (11), 1593-1597 PubMed.

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!

 
 
 
 

To show you are not a Bot please can you enter the number showing adjacent to this field

 Security code