ISSN 2398-2950      

Pancytopenia

ffelis

Introduction

  • Cause: toxin (including drugs), infection (eg viral, protozoal, bacterial), neoplasia, immune-mediated disease, idiopathic.
  • Definition: leukopenia, thrombocytopenia and low platelet count.
  • Diagnosis: complete blood cell count including microscopic evaluation of blood smear. To establish an underlying cause bone marrow examination is often required.
  • Treatment: supportive (including transfusion of red blood cells, antibiotic therapy); more specific treatments depending on underlying cause.
  • Prognosis: guarded to poor, depending on underlying cause.
Pancytopenia is a relatively rare condition in cats and in light of a current increase in cases, all cats with pancytopenia should be logged at http://rvc.onlinesurveys.ac.uk/pancytopenia Print off the owner factsheet Pancytopenia in cats to give to your client.

Pathogenesis

Etiology

  • Etiology for the recent increase in feline pancytopenia cases remains unclear, an epidemiological link to certain feline feed has been noted.

Predisposing factors

General

  • Unknown.

Pathophysiology

  • Dependent on the underlying cause - different pathophysiological mechanism resulting in either destruction of hematopoietic precursor cells or in an ineffective production of all blood cells.

Timecourse

  • Unknown.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMedResource.
  • Glanemann B, Humm K (2021) Rare presentation of severe pancytopenia in cats. Vet Rec 188(11), 438 PubMed.
  • Stanley E L, Eatroff A E (2017) Hypocobalaminaemia as a cause of bone marrow failure and pancytopenia in a cat. Aust Vet J 95(5), 156-160 PubMed.
  • Marcos R, Santos M, Malhão F, Pereira R, Fernandes A C, Montenegro L, Roccabianca P (2009) Pancytopenia in a cat with visceral leishmaniasis. Vet Clin Pathol 38(2), 201-215 PubMed.

Other sources of information

For the current status of this condition please refer to: https://www.rvc.ac.uk/news-and-events/rvc-news/feline-pancytopenia-update  

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