Felis ISSN 2398-2950

Pancreas: neoplasia

Contributor(s): Andrew Gardiner

Introduction

  • Cause: neoplasia of exocrine or endocrine pancreas is rare:
    • Exocrine:
      • Adenocarcinoma.
      • Nodular hyperplasia.
      • Adenoma.
    • Endocrine:
  • Signs: pancreatitis Pancreatitis, jaundice, hypoglycemia Hypoglycemia.
  • Diagnosis: laboratory tests, ultrasonography, exploratory laparotomy.
  • Treatment: surgical resection insulin-secreting tumors.
  • Medical treatment for pancreatitis may be needed additionally after surgery.
  • Prognosis; poor; high incidence of metastasis from pancreatic neoplasms.
  • Euthanasia should be considered.

Pathogenesis

Pathophysiology

  • Beta-cell neoplasia results in hypoglycemia which produces the mainly neurological clinical signs of weakness, collapse, lethargy.
  • Malignancy is common and complications related to this can be expected.

Timecourse

  • Little information available in the cat.
  • In dogs the condition may be present for some considerable time before clinical signs develop to the stage where attention is sought.
  • The malignant nature of pancreatic tumors means prognosis is always guarded.
  • Pancreatitis per se may be a recurring medical problem.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Nicoletti R, Chun R, Curran K M et al (2018) Postsurgical outcome in cats withe exocrine pancreatic carcinoma: nine cases (2007-2016). J Am Anim Hosp Assoc 54(5), 291-295 PubMed.
  • Bennett P F, Hahn K A, Toal R L et al (2001) Ultrasonographic and cytopathological diagnosis of exocrine pancreatic carcinoma in the dog and cat. J Am Anim Hosp Assoc 37 (5), 466-473 PubMed.
  • Tasker S, Griffon D J, Nuttall T J et al (1999) Resolution of paraneoplastic alopecia following surgical removal of a pancreatic carcinoma in a cat. JSAP 40 (1), 16-19 PubMed.
  • Brooks D G, Campbell K L, Dennis J S et al (1994) Pancreatic paraneoplastic alopecia in three cats. JAAHA 30 (6), 557-63 VetMedResource.


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