Felis ISSN 2398-2950

Neuroaxonal dystrophy

Synonym(s): NAD

Contributor(s): Kaspar Matiasek, Laurent Garosi

Introduction

  • Fatal, progressive neurodegenerative disorder.
  • Cerebellar-like clinical signs progressing to paresis.
  • Hereditary in domestic short-haired and Siamese cats.
  • No treatment.

Pathogenesis

Etiology

  • An autosomal-recessive inheritance most probable.

Pathophysiology

  • Current concepts of pathogenesis of both, inherited and physiologic, NADs in cats suggest a disruption of the axonal transport system leading to a functional transsection of the nerve fiber.

Timecourse

  • NAD is a monophasic and progressive disease.
  • The speed of deterioration may differ from days to weeks.
  • Euthanasia Euthanasia is usually necessary when severe paresis is evident.

Diagnosis

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Treatment

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Prevention

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Résibois A & Poncelet L (2004) Purkinje cell neuroaxonal dystrophy similar to nervous mutant mice phenotype in two sibling kittens. Acta Neuropathol 107 (6), 553-558 PubMed.
  • Anada S, Mochizuki M, Izumo S et al (1996) Study of hereditary cerebellar degeneration in cats. Am J Vet Res 57 (3), 296-301 PubMed.
  • Rodriguez F, Espinosa de los Monteros A, Morales M et al (1996) Neuroaxonal dystrophy in two Siamese kitten littermates. Vet Rec 138 (22), 548-549 PubMed.
  • Carmichael K P, Howerth E W, Oliver J E Jr. et al (1993) Neuroaxonal dystrophy in a group of related cats. J Vet Diag Invest (4), 585-590 PubMed.
  • Woodward J C, Collins G H, Hessler J R (1974) Feline hereditary neuroaxonal dystrophy. Am J Pathol 74 (3), 551-566 PubMed.

Other sources of information

  • Braund K G (2003) Degenerative disorders of the central nervous system. In: Braund K G (ed) Clinical neurology in small animals localization, diagnosis and treatment. International Veterinary Information Service (www.ivis.org), Ithaca, New York.
  • Lowe J S, Leigh P (2002) Disorders of movement and system degenerations. In: Graham D, Lantos P (eds) Greenfield's Neuropathology. 7th edn, Arnold, London, pp 281-366.
  • Summers B A, Cummings J F, De Lahunta A (1995) Veterinary Neuropathology. Mosby, St Louis, pp 315-317.


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