Felis ISSN 2398-2950

Mastocytoma

Synonym(s): Mast cell tumour

Contributor(s): William Brewer Jr, Susan North, David Scarff

Introduction

  • Less common than dog but 15% of all feline tumors.
  • Cutaneous and visceral forms.
  • Diagnosis: cytology, histopathology.
  • Treatment: surgical excision, radiotherapy, chemotherapy.
  • Prognosis: cutaneous: good; visceral: poor.

Pathogenesis

Predisposing factors

General

  • Breed - Siamese   Siamese  for cutaneous form.

Pathophysiology

  • Most cutaneous tumors benign or regress.
  • Occasionally metastatic spread to lymph nodes and or internal organs.
  • Primary visceral tumors metastasize frequently to other organs.
  • Multiple cutaneous tumors, may have appearance of miliary dermatitis   Dermatitis: miliary  (rare).
  • Primary mass not usually a major problem.
  • Histiocytic - spontaneous regression over 4-24 months.
  • Typical - majority behaviorally benign.
  • Variable metastatic rate reported for malignant tumors - spread to local lymph node and/or distant sites.

Visceral

  • Widespread metastasis common to liver and spleen, visceral lymph nodes, bone marrow, leading to hepato-splenomegaly, depression, anorexia, vomiting, diarrhea, weight loss, intestinal obstruction, peritoneal effusion.
  • Peripheral mastocytosis/anemia relatively common with splenic form.
  • Splenomegaly may be present for a long time before clinical disease seen.

Diagnosis

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Treatment

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Outcomes

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Further Reading

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