Felis ISSN 2398-2950

Kidney: neoplasia

Contributor(s): William Brewer Jr, Irene Rochlitz

Introduction

  • Lymphoma is by far the most common renal tumor, is usually bilateral and sometimes occurs with multicentric or alimentary lymphoma Lymphoma.
  • Other renal tumors are rare.
    • Renal carcinoma.
    • Adenocarcinoma.
    • Nephroblastoma.
    • Unclassified sarcoma.
  • Benign renal adenomas occur very rarely.
  • Signs: renal failure, or non-specific signs attributable to tumor burden.
  • Diagnosis: ultrasonography histopathology.
  • Treatment: chemotherapy for lymphosarcoma, surgical for other renal tumors.
  • Prognosis: for renal lymphoma poor, although may see some response to chemotherapy, other renal tumors metastasize to regional lymph nodes, lung, liver and bone in up to 50% of cases.

Pathogenesis

Etiology

  • Renal lymphoma: 50% of cases FeLV FeLV test positive.

Pathophysiology

  • Neoplasm arising in kidney   →   impairs normal renal function.
  • If both kidneys extensively involved   →   azotemia and signs of renal failure Kidney: chronic kidney disease.
  • Anemia Anemia: overview develops secondary to renal failure or may be the result of blood loss via hematuria.
  • If only one kidney involved azotemia does not develop, unless renal function in other kidney compromised for another reason.

Renal lymphoma

  • Renal lymphoma Lymphoma commonly accompanied by intestinal, CNS and/or nasal lymphoma or sometimes multicentric lymphoma.
  • Usually bilateral.

Other renal tumors

  • Most are malignant.
  • Often metastasize to local lymph node, lungs, liver or bone.
  • May extend through capsule and be locally invasive.

Timecourse

  • Lymphoma: develops rapidly.
  • Other renal tumors may have more gradual onset.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Henry C J, Turnquist S E, Smith A et al (1999) Primary renal tumours in cats - 19 cases (1992-1998). J Feline Med & Surg (3), 165-70 PubMed.
  • Clark W R & Wilson R B (1988) Renal adenoma in a cat. JAVMA 193 (12), 1557-1559 PubMed.
  • Weller R E & Stann S E (1983) Renal lymphosarcoma in the cat. JAVMA 19 (3), 363-367 VetMedResource.

Other sources of information

  • Couto C G (1988) Oncology. In: Sherding, R G (ed) The Cat. diseases and Clinical Management. New York Churchill Livingstone, 1988, pp 589 - 647.


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