Felis ISSN 2398-2950

Kidney: ischemia

Synonym(s): Renal ischemia

Contributor(s): Penney Barber

Introduction

  • Cause: multiple potential events that can lead to renal ischemia.
  • Signs: same as acute renal failure Kidney: acute renal failure.
  • Diagnosis: histopathology.
  • Treatment: supportive care only to try to prevent renal failure.
  • Prognosis: acute renal failure if renal ischemia not corrected quickly.

Pathogenesis

Etiology

Pathophysiology

  • Renal ischemia   →   decreased intracellular ATP   →   decreased function of Na-K and Na-Ca ATP-ase pumps   →   increased intracellular Na and Ca   →   increased intracellular osmotic pressure   →   swelling of tubular cells and sludging and aggregation in renal blood vessels   →   further decrease in renal blood flow.
  • Renal ischemia   →   increase in oxygen free radical formation   →   further damage cell membranes.
  • Severe damage to the renal cells   →   acute renal failure.

Timecourse

  • Acute.

Diagnosis

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Prevention

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Outcomes

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Further Reading

Publications

Refereed papers


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