Felis ISSN 2398-2950

Idiopathic polymyositis

Synonym(s): Immune-mediated polymyositis

Contributor(s): Vetstream Ltd, Laurent Garosi

Introduction

  • Cause: suspected immune-mediated.
  • Signs: weakness, reluctance to jump, stiff-stilted gait, muscle atrophy.
  • Diagnosis: elevated CK, muscle biopsy, ruling-out infectious causes.
  • Treatment: immune-suppressive therapy with prednisolone.
  • Prognosis: fair although relapses may occur.
Print off the owner factsheet on Myositis Myositis to give to your client.

Pathogenesis

Etiology

  • Cause unknown, although responsiveness of disease to immunosuppressive therapy suggests immune-mediated pathogenesis.
  •  Can be paraneoplastic syndrome secondary to tumor such as thymoma Thymoma.

Predisposing factors

General

  • None identified.

Pathophysiology

  • Polymyositis suspected to be autoimmune in origin.
  • Rarely can be secondary to thymoma.

Timecourse

  • Timecourse of disease extremely variable depending on predominant clinical signs.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Ginman A A, Kline K L, Shelton G D (2009) Severe polymyositis and neuritis in a cat. J Am Vet Med Assoc 235 (2), 172-175 PubMed.
  • Sura R, Hinckley L S, Risatti G R et al (2008) Fatal necrotising fasciitis and myositis in a cat associated with Streptococcus canis. Vet Rec 162 (14), 450-453 PubMed.
  • Dickinson P J, LeCouteur R A (2004) Feline neuromuscular disorders. Vet Clin North Am Small Anim Pract 34 (6), 1307-1359 PubMed.
  • Podell M (2002) Inflammatory myopathies. Vet Clin North Am: Sm Anim Pract 32 (1), 147-167 PubMed.


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